| pubmed-article:20618737 | pubmed:abstractText | We report three benign nodular goiters associated with spindle cell component. The spindle cells were bland, and showed short fascicular pattern or formed small nests. The cytoplasm was pale or clear. A transition between follicular cells and the spindle cells was observed. Immunohistochemically, they were positive for thyroglobulin and thyroid transcription factor-1. They did not react against CD34. Ki-67 (MIB-1) labeling indexes were less than 1%. We thought that the spindle cells are derived from follicular cell and non-neoplastic, and it is important to recognize this lesion to distinguish from aggressive and lethal components seen in papillary carcinoma or anaplastic carcinoma. | lld:pubmed |
