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pubmed-article:20616956pubmed:abstractTextProstate cancer is one of the most common cancers in men in US and European countries. Despite having a favorable prognosis, the incidence of incurable metastatic disease and mortality in the US is about 28,000 per year. Although hormone-based androgen deprivation therapies typically result in rapid responses, nearly all patients eventually develop progressive castration-resistant disease state. With readily available prostate-specific antigen (PSA) testing, most of these patients are asymptomatic and manifest progression simply as a rising PSA. In patients with castration-resistant prostate cancer (CRPC), the median survival is about 1-2 years, with improvements in survival seen mostly with docetaxel-based regimens. The purpose of this article is to review the recent developments in the treatment of advanced CRPC.lld:pubmed
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pubmed-article:20616956pubmed:authorpubmed-author:TanWinston...lld:pubmed
pubmed-article:20616956pubmed:authorpubmed-author:VishnuPrakash...lld:pubmed
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pubmed-article:20616956pubmed:pagination39-51lld:pubmed
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pubmed-article:20616956pubmed:articleTitleUpdate on options for treatment of metastatic castration-resistant prostate cancer.lld:pubmed
pubmed-article:20616956pubmed:affiliationDivision of Hematology Oncology, Mayo Clinic, Jacksonville, FL, USA.lld:pubmed
pubmed-article:20616956pubmed:publicationTypeJournal Articlelld:pubmed
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