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pubmed-article:20609193pubmed:abstractTextLambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular transmission disease caused by autoantibodies directed against voltage-gated calcium channels (VGCC). We report on a patient with LEMS and a cerebellar syndrome associated with lymphatic proliferation in the thymus. As thymectomy and immunosuppressive therapy failed to efficiently reduce clinical symptoms and VGCC antibody titer, we performed immunoadsorption using a tryptophan-ligand column for the first time. Repeated treatments resulted in a considerable decrease in antibody levels and a marked subjective and objective amelioration of LEMS as well as of the cerebellar symptoms.lld:pubmed
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pubmed-article:20609193pubmed:articleTitleA case report of the efficient reduction of calcium channel antibodies by tryptophan ligand immunoadsorption in a patient with Lambert-Eaton syndrome.lld:pubmed
pubmed-article:20609193pubmed:affiliationMedical Policlinic, Department of Nephrology, University of Munich, Munich, Germany. Matthias.Sauter@med.uni-muenchen.delld:pubmed
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