| pubmed-article:20599938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20599938 | lifeskim:mentions | umls-concept:C0027059 | lld:lifeskim |
| pubmed-article:20599938 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:20599938 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:20599938 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:20599938 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20599938 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:20599938 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20599938 | pubmed:dateCreated | 2010-9-13 | lld:pubmed |
| pubmed-article:20599938 | pubmed:abstractText | A protective effect of interferon-gamma (IFN?) has been described in a number of models of autoimmune disease, including experimental autoimmune myocarditis (EAM). Some reports have suggested that regulation of apoptosis in autoreactive lymphocytes mediate these protective functions. We examined the potential of IFN? to regulate apoptotic mechanisms in detail, both in vitro and in vivo in EAM. We observed multiple apoptotic defects in caspase activity, and the expression of TNF superfamily members on CD4(+) T cells. In addition, we observed selective defects in CD4(+) T cell activation in response to antigenic stimulation. These activation and apoptotic defects were CD4(+) cell autonomous, independent of the genotype of APCs. Inhibition of nitric oxide production in vivo did not reproduce the severe form of EAM of IFN?-deficient mice, indicating that this pathway does not mediate the protective effect of IFN?. Crosswise adoptive transfer of wild type, IFN?(-/-), and IFN?R(-/-)EAM demonstrated that IFN? signaling was critical in CD4(+) cells, but that non-CD4(+) sources of IFN? production were also involved in the control of disease. Together, these data indicate multiple mechanisms of autonomous and non-autonomous CD4(+) T cell regulation mediated by IFN? in the control of autoimmune heart disease. | lld:pubmed |
| pubmed-article:20599938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20599938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20599938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20599938 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20599938 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20599938 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20599938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20599938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20599938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20599938 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20599938 | pubmed:issn | 1096-0945 | lld:pubmed |
| pubmed-article:20599938 | pubmed:author | pubmed-author:RoseNoel RNR | lld:pubmed |
| pubmed-article:20599938 | pubmed:author | pubmed-author:CihákováDanie... | lld:pubmed |
| pubmed-article:20599938 | pubmed:author | pubmed-author:KimuraMihoM | lld:pubmed |
| pubmed-article:20599938 | pubmed:author | pubmed-author:BarinJobert... | lld:pubmed |
| pubmed-article:20599938 | pubmed:author | pubmed-author:TalorMonica... | lld:pubmed |
| pubmed-article:20599938 | pubmed:author | pubmed-author:BaldevianoG... | lld:pubmed |
| pubmed-article:20599938 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20599938 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20599938 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:20599938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20599938 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20599938 | pubmed:pagination | 83-91 | lld:pubmed |
| pubmed-article:20599938 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:meshHeading | pubmed-meshheading:20599938... | lld:pubmed |
| pubmed-article:20599938 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20599938 | pubmed:articleTitle | Mechanisms of IFN? regulation of autoimmune myocarditis. | lld:pubmed |
| pubmed-article:20599938 | pubmed:affiliation | Training Program in Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. | lld:pubmed |
| pubmed-article:20599938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20599938 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20599938 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
