| pubmed-article:20594918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20594918 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20594918 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:20594918 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:20594918 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:20594918 | lifeskim:mentions | umls-concept:C2924423 | lld:lifeskim |
| pubmed-article:20594918 | lifeskim:mentions | umls-concept:C0018591 | lld:lifeskim |
| pubmed-article:20594918 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20594918 | pubmed:dateCreated | 2010-9-17 | lld:pubmed |
| pubmed-article:20594918 | pubmed:abstractText | We have evaluated the role of the HLA-DRB1*1501 allele and the IL-2 -330 T/G polymorphism and their interaction in susceptibility to multiple sclerosis on 360 patients and 426 matched healthy individuals. We used the SSP-PCR method to determine the alleles. Fisher's exact test was used to analyses. We observed a significant increase in the T allele at IL-2 -330 position in patients (OR=1.34, P<0.05), and the T/T and T/G genotypes were more frequent among patients than controls. The HLA-DRB1*1501 allele was overrepresented in patients as compared to the control group (OR=1.7, P=0.0006). The two-locus analysis of the interaction between the IL-2 promoter polymorphism and the HLA-DRB1 allele showed that the HLA-DRB1*1501/T haplotype was more frequent in patients than controls (OR=16, P<0.0001). Our findings support previous findings about the role of the HLA-DRB1*1501 allele in susceptibility to MS. This work also provides new findings about the importance of gene-gene interactions in the development of MS. | lld:pubmed |
| pubmed-article:20594918 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20594918 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20594918 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20594918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20594918 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20594918 | pubmed:issn | 1521-7035 | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:ShahbaziMajid... | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:ZamaniMahdiM | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:RoshandelDani... | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:ShahbaziSaleh... | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:EbadiHamidH | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:FathiDavoodD | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:BoghaeeMojdeh... | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:Mohammadhosee... | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:RshaidbaghanA... | lld:pubmed |
| pubmed-article:20594918 | pubmed:author | pubmed-author:BakhshandehAz... | lld:pubmed |
| pubmed-article:20594918 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20594918 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20594918 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:20594918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20594918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20594918 | pubmed:pagination | 134-8 | lld:pubmed |
| pubmed-article:20594918 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:20594918 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20594918 | pubmed:articleTitle | High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis. | lld:pubmed |
| pubmed-article:20594918 | pubmed:affiliation | Medical Cellular & Molecular Research Center, Talghani Children Hospital of Golestan University of Medical Sciences, Bolv Janbazan, 4916668197, Gorgan, Iran. shahbazimajid@yahoo.co.uk | lld:pubmed |
| pubmed-article:20594918 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20594918 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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