| pubmed-article:20562105 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20562105 | lifeskim:mentions | umls-concept:C1328818 | lld:lifeskim |
| pubmed-article:20562105 | lifeskim:mentions | umls-concept:C0178664 | lld:lifeskim |
| pubmed-article:20562105 | lifeskim:mentions | umls-concept:C0007578 | lld:lifeskim |
| pubmed-article:20562105 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:20562105 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:20562105 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:20562105 | pubmed:issue | 33 | lld:pubmed |
| pubmed-article:20562105 | pubmed:dateCreated | 2010-8-9 | lld:pubmed |
| pubmed-article:20562105 | pubmed:abstractText | Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage renal disease worldwide. Although the mechanisms underlying this important disease are poorly understood, the glomerular podocyte clearly plays a central role in disease pathogenesis. In the current work, we demonstrate that the homophilic adhesion molecule sidekick-1 (sdk-1) is up-regulated in podocytes in FSGS both in rodent models and in human kidney biopsy samples. Transgenic mice that have podocyte-specific overexpression of sdk-1 develop gradually progressive heavy proteinuria and severe FSGS. We also show that sdk-1 associates with the slit diaphragm linker protein MAGI-1, which is already known to interact with several critical podocyte proteins including synaptopodin, alpha-actinin-4, nephrin, JAM4, and beta-catenin. This interaction is mediated through a direct interaction between the carboxyl terminus of sdk-1 and specific PDZ domains of MAGI-1. In vitro expression of sdk-1 enables a dramatic recruitment of MAGI-1 to the cell membrane. Furthermore, a truncated version of sdk-1 that is unable to bind to MAGI-1 does not induce podocyte dysfunction when overexpressed. We conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in FSGS and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function. | lld:pubmed |
| pubmed-article:20562105 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20562105 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20562105 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20562105 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20562105 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:KlotmanPaul... | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:HataYutakaY | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:D'AgatiVivett... | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:KuriharaHidet... | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:ColemanSarahS | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:KaufmanLewisL | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:HeJohn CJC | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:PotlaUmaU | lld:pubmed |
| pubmed-article:20562105 | pubmed:author | pubmed-author:DikiyStanisla... | lld:pubmed |
| pubmed-article:20562105 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20562105 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:20562105 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:20562105 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20562105 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20562105 | pubmed:pagination | 25677-85 | lld:pubmed |
| pubmed-article:20562105 | pubmed:dateRevised | 2011-8-25 | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
| pubmed-article:20562105 | pubmed:meshHeading | pubmed-meshheading:20562105... | lld:pubmed |
