| pubmed-article:20542439 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C0058698 | lld:lifeskim |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C2917388 | lld:lifeskim |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C0536540 | lld:lifeskim |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C0537916 | lld:lifeskim |
| pubmed-article:20542439 | lifeskim:mentions | umls-concept:C0256338 | lld:lifeskim |
| pubmed-article:20542439 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:20542439 | pubmed:dateCreated | 2010-7-13 | lld:pubmed |
| pubmed-article:20542439 | pubmed:abstractText | A series of indole, 7-azaindole, benzofuran, and benzothiophene compounds have been prepared and evaluated for affinity at D2-like dopamine receptors. These compounds share structural elements with the classical D2-like dopamine receptor antagonists haloperidol, N-methylspiperone and benperidol. Two new compounds, 4-(4-iodophenyl)-1-((4-methoxy-1H-indol-3-yl)methyl)piperidin-4-ol (6) and 4-(4-iodophenyl)-1-((5-methoxy-1H-indol-3-yl)methyl)piperidin-4-ol (7), were found to have high affinity to and selectivity for D2 versus D3 receptors. Changing the aromatic ring system from an indole to other heteroaromatic ring systems reduced the D2 binding affinity and the D2 versus D3 selectivity. | lld:pubmed |
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| pubmed-article:20542439 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20542439 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20542439 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20542439 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20542439 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20542439 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:20542439 | pubmed:author | pubmed-author:MachRobert... | lld:pubmed |
| pubmed-article:20542439 | pubmed:author | pubmed-author:XuJinbinJ | lld:pubmed |
| pubmed-article:20542439 | pubmed:author | pubmed-author:LuedtkeRobert... | lld:pubmed |
| pubmed-article:20542439 | pubmed:author | pubmed-author:VangveravongS... | lld:pubmed |
| pubmed-article:20542439 | pubmed:author | pubmed-author:TaylorMichell... | lld:pubmed |
| pubmed-article:20542439 | pubmed:author | pubmed-author:CuiJinquanJ | lld:pubmed |
| pubmed-article:20542439 | pubmed:author | pubmed-author:CalvinWesleyW | lld:pubmed |
| pubmed-article:20542439 | pubmed:author | pubmed-author:BabicSonjaS | lld:pubmed |
| pubmed-article:20542439 | pubmed:copyrightInfo | Copyright (c) 2010. Published by Elsevier Ltd. | lld:pubmed |
| pubmed-article:20542439 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20542439 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20542439 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:20542439 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20542439 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20542439 | pubmed:pagination | 5291-300 | lld:pubmed |
| pubmed-article:20542439 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:meshHeading | pubmed-meshheading:20542439... | lld:pubmed |
| pubmed-article:20542439 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20542439 | pubmed:articleTitle | Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. | lld:pubmed |
| pubmed-article:20542439 | pubmed:affiliation | Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110, USA. | lld:pubmed |
| pubmed-article:20542439 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20542439 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20542439 | lld:chembl |
