| pubmed-article:20537899 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C0684309 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C2700455 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C0233794 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C0031678 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C1704708 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C0074765 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C0255156 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C1947974 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20537899 | lifeskim:mentions | umls-concept:C1720655 | lld:lifeskim |
| pubmed-article:20537899 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20537899 | pubmed:dateCreated | 2010-7-12 | lld:pubmed |
| pubmed-article:20537899 | pubmed:abstractText | Neurofibrillary tangles composed of abnormally hyperphosphorylated tau protein are a hallmark of Alzheimer's disease (AD) and related tauopathies. Tau hyperphosphorylation is thought to promote aggregation with subsequent tangle formation. Reducing tau phosphorylation by boosting the activity of the key phosphatase/s that mediate dephosphorylation of tau could be a viable clinical strategy in AD. One of the key phosphatases implicated in regulating tau protein phosphorylation is the serine-threonine phosphatase PP2A. We have determined that sodium selenate can act as a specific agonist for PP2A, significantly boosting phosphatase activity. Acute treatment of either neuroblastoma cells or normal aged mice with sodium selenate rapidly reduced tau protein phosphorylation. Sodium selenate-treated transgenic TAU441 mice had significantly lower levels of phospho- and total tau levels in the hippocampus and amygdala compared with controls and exhibited significantly improved spatial learning and memory on the Morris Water Maze task. Sodium selenate is a specific activator of PP2A with excellent oral bioavailability, and favourable central nervous system penetrating properties. Clinical studies in patients with AD are envisaged in the near future. | lld:pubmed |
| pubmed-article:20537899 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20537899 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20537899 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20537899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20537899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20537899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20537899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20537899 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20537899 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20537899 | pubmed:issn | 1532-2653 | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:HuM JMJ | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:WindischManfr... | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:CostelloAntho... | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:Hutter-PaierB... | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:MartinDanielD | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:SundstromLars... | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:NguyenThanhT | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:CorcoranNiall... | lld:pubmed |
| pubmed-article:20537899 | pubmed:author | pubmed-author:HovensChristo... | lld:pubmed |
| pubmed-article:20537899 | pubmed:copyrightInfo | Copyright 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20537899 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20537899 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:20537899 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20537899 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20537899 | pubmed:pagination | 1025-33 | lld:pubmed |
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| pubmed-article:20537899 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20537899 | pubmed:articleTitle | Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model. | lld:pubmed |
| pubmed-article:20537899 | pubmed:affiliation | Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville 3010, Victoria, Australia. niallmcorcoran@gmail.com | lld:pubmed |
| pubmed-article:20537899 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20537899 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20537899 | lld:pubmed |
