| pubmed-article:20505260 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20505260 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20505260 | lifeskim:mentions | umls-concept:C1556094 | lld:lifeskim |
| pubmed-article:20505260 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:20505260 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:20505260 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:20505260 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20505260 | pubmed:dateCreated | 2010-8-4 | lld:pubmed |
| pubmed-article:20505260 | pubmed:abstractText | Circulating anti-islet autoantibodies in sera are used as a predictive marker for type 1 diabetes (T1D). We here report two Japanese patients with autoimmune thyroid disease complicated with T1D in whom the time course of anti-islet autoantibodies were observed before the clinical onset of diabetes. Case 1: A woman who had developed Graves' disease at age 25 was diagnosed with type 2 diabetes at age 31; six months later, insulin therapy was started. At age 36 she was diagnosed with T1D due to glutamic acid decarboxylase 65 autoantibodies (GAD65Ab)-positive status and decreased C-peptide levels. With stored sera we retrospectively followed her anti-islet autoantibodies. GAD65Ab, zinc transporter 8 autoantibodies (ZnT8Ab) and insulin autoantibodies (IAA) were found to be positive at age 25. IAA soon turned negative, but GAD65Ab and ZnT8Ab remained positive with high levels. Insulinoma-associated antigen-2 autoantibodies (IA-2Ab) emerged 2 years before the initiation of insulin therapy. She has T1D-susceptible HLA-DRB1-DQB1 haplotypes, (*)0405- (*)0401/(*)0802-(*)0302. Case 2: A 49-year-old woman with hypothyroidism due to 19 years' history of atrophic thyroiditis noticed marked thirst, polyuria and weight loss. On admission she was diagnosed as T1D due to GAD65Ab-positive findings and poor C-peptide response to i.v. glucagon. Retrospective serology revealed the emergence of GAD65Ab and IAA just after the clinical onset. IA-2Ab and ZnT8Ab never developed. She has T1D-susceptible and -resistant HLADRB1- DQB1 haplotypes, (*)0901-(*)0303/(*)1502-(*)0601. The autoantibody profile and the mode of diabetes onset in the two cases were remarkably different. These cases imply that anti-islet autoantibodies do not always precede the onset of T1D. | lld:pubmed |
| pubmed-article:20505260 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20505260 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20505260 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20505260 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20505260 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20505260 | pubmed:issn | 1348-4540 | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:AndoTakaoT | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:EguchiKatsumi... | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:AbiruNorioN | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:KawasakiEijiE | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:KuwaharaHiron... | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:SatohTsuyoshi... | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:UsaToshiroT | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:HorieIchiroI | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:ShimomuraAyaA | lld:pubmed |
| pubmed-article:20505260 | pubmed:author | pubmed-author:UekiIkukoI | lld:pubmed |
| pubmed-article:20505260 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20505260 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:20505260 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20505260 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20505260 | pubmed:pagination | 623-8 | lld:pubmed |
| pubmed-article:20505260 | pubmed:dateRevised | 2011-6-16 | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:meshHeading | pubmed-meshheading:20505260... | lld:pubmed |
| pubmed-article:20505260 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20505260 | pubmed:articleTitle | Emergence of anti-islet autoantibodies in Japanese patients with type 1 diabetes. | lld:pubmed |
| pubmed-article:20505260 | pubmed:affiliation | First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. | lld:pubmed |
| pubmed-article:20505260 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20505260 | pubmed:publicationType | Case Reports | lld:pubmed |
