Linked Life Data

20484412

Source:http://linkedlifedata.com/resource/pubmed/id/20484412

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SubjectPredicateObjectContext
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pubmed-article:20484412pubmed:issue11lld:pubmed
pubmed-article:20484412pubmed:dateCreated2010-10-28lld:pubmed
pubmed-article:20484412pubmed:abstractTextSteroid hormones regulate gene expression by interaction of their receptors with hormone-responsive elements on DNA or with other transcription factors, but they can also activate cytoplasmic signaling cascades. Rapid activation of Erk by progestins via an interaction of the progesterone receptor (PR) with the estrogen receptor is critical for transcriptional activation of the mouse mammary tumor virus (MMTV) promoter and other progesterone target genes. Erk activation leads to the phosphorylation of PR, activation of mitogen- and stress-activated protein kinase 1, and the recruitment of a complex of the three activated proteins and of P300/CBP-associated factor (PCAF) to a single nucleosome, resulting in the phosphoacetylation of histone H3 and the displacement of heterochromatin protein 1?. Hormone-dependent gene expression requires ATP-dependent chromatin remodeling complexes. Two switch/sucrose nonfermentable-like complexes, Brahma-related gene 1-associated factor (BAF) and polybromo-BAF are present in breast cancer cells, but only BAF is recruited to the MMTV promoter and cooperates with PCAF during activation of hormone-responsive promoters. PCAF acetylates histone H3 at K14, an epigenetic mark recognized by BAF subunits, thus anchoring the complex to chromatin. BAF catalyzes localized displacement of histones H2A and H2B, facilitating access of nuclear factor 1 and additional PR complexes to the hidden hormone-responsive elements on the MMTV promoter. The linker histone H1 is a structural component of chromatin generally regarded as a general repressor of transcription. However, it contributes to a better regulation of the MMTV promoter by favoring a more homogeneous nucleosome positioning, thus reducing basal transcription and actually enhancing hormone induced transcription. During transcriptional activation, H1 is phosphorylated and displaced from the promoter. The kinase cyclin-dependent kinase 2 is activated after progesterone treatment and could catalyze progesterone-induced phosphorylation of histone H1 by chromatin remodeling complexes. The initial steps of gene induction by progestins involve changes in the chromatin organization of target promoters that require the activation of several kinase signaling pathways initiated by membrane anchored PR. Because these pathways also respond to other external signals, they serve to integrate the hormonal response in the global context of the cellular environment.lld:pubmed
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pubmed-article:20484412pubmed:authorpubmed-author:BeatoMiguelMlld:pubmed
pubmed-article:20484412pubmed:authorpubmed-author:VicentGuiller...lld:pubmed
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pubmed-article:20484412pubmed:authorpubmed-author:ZaurínRoserRlld:pubmed
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pubmed-article:20484412pubmed:pagination2088-98lld:pubmed
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pubmed-article:20484412pubmed:year2010lld:pubmed
pubmed-article:20484412pubmed:articleTitleMinireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin.lld:pubmed
pubmed-article:20484412pubmed:affiliationCentre de Regulació Genòmica, Universitat Pompeu Fabra, Parc de Recerca Biomèdica, Aiguader 88, E-08003 Barcelona, Spain. guillermo.vicent@crg.eslld:pubmed
pubmed-article:20484412pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:20484412pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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