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pubmed-article:20482749pubmed:abstractTextKlotho was originally characterized as an anti-aging gene that predisposed Klotho-deficient mice to a premature aging-like syndrome. Recently, KLOTHO was reported to function as a secreted Wnt antagonist and as a tumor suppressor. Epigenetic gene silencing of secreted Wnt antagonists is considered a common event in a wide range of human malignancies. Abnormal activation of the canonical Wnt pathway due to epigenetic deregulation of Wnt antagonists is thought to play a crucial role in cervical tumorigenesis. In this study, we examined epigenetic silencing of KLOTHO in human cervical carcinoma.lld:pubmed
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pubmed-article:20482749pubmed:articleTitleThe anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma.lld:pubmed
pubmed-article:20482749pubmed:affiliationResearch Center for Women's Diseases and Division of Biological Science, Sookmyung Women's University, Seoul 140-742, Republic of Korea.lld:pubmed
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