| pubmed-article:20457197 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20457197 | lifeskim:mentions | umls-concept:C0035567 | lld:lifeskim |
| pubmed-article:20457197 | lifeskim:mentions | umls-concept:C0036563 | lld:lifeskim |
| pubmed-article:20457197 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:20457197 | lifeskim:mentions | umls-concept:C1325683 | lld:lifeskim |
| pubmed-article:20457197 | lifeskim:mentions | umls-concept:C0042444 | lld:lifeskim |
| pubmed-article:20457197 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:20457197 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
| pubmed-article:20457197 | lifeskim:mentions | umls-concept:C0348005 | lld:lifeskim |
| pubmed-article:20457197 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20457197 | pubmed:dateCreated | 2010-7-16 | lld:pubmed |
| pubmed-article:20457197 | pubmed:abstractText | Mucosal delivery of peptide/protein therapeutics via the oral route is a desirable strategy in human immunotherapy. A key step for enhancing the bioavailability of orally administered therapeutics is to protect them from enzymatic digestion in the gastrointestinal tract. Here, we generated transgenic rice seeds accumulating allergen-derived T cell epitopes, a model tolerogen for the control of pollen allergy, in either ER-derived protein body-I (PB-I) or protein storage vacuole protein body-II (PB-II). Compared with PB-II-localized or chemically synthesized forms, PB-I-localized T cell epitopes showed higher resistance to enzymatic digestion in simulated gastric fluid. Moreover, the dose of T cell epitope required for suppression of allergen-specific IgE in mice was about 20-fold lower when fed in PB-I localized form than when unprotected. These findings demonstrate the potential of bioencapsulation in PB-I for broad applications as a viable strategy to achieve efficient mucosal delivery of oral peptide/protein therapeutics. | lld:pubmed |
| pubmed-article:20457197 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20457197 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20457197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457197 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20457197 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20457197 | pubmed:issn | 1873-5169 | lld:pubmed |
| pubmed-article:20457197 | pubmed:author | pubmed-author:HiroiTakachik... | lld:pubmed |
| pubmed-article:20457197 | pubmed:author | pubmed-author:TakaiwaFumioF | lld:pubmed |
| pubmed-article:20457197 | pubmed:author | pubmed-author:YangLijunL | lld:pubmed |
| pubmed-article:20457197 | pubmed:author | pubmed-author:TakagiHidenor... | lld:pubmed |
| pubmed-article:20457197 | pubmed:author | pubmed-author:HiroseSakikoS | lld:pubmed |
| pubmed-article:20457197 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20457197 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20457197 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:20457197 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20457197 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20457197 | pubmed:pagination | 1421-5 | lld:pubmed |
| pubmed-article:20457197 | pubmed:meshHeading | pubmed-meshheading:20457197... | lld:pubmed |
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| pubmed-article:20457197 | pubmed:meshHeading | pubmed-meshheading:20457197... | lld:pubmed |
| pubmed-article:20457197 | pubmed:meshHeading | pubmed-meshheading:20457197... | lld:pubmed |
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| pubmed-article:20457197 | pubmed:meshHeading | pubmed-meshheading:20457197... | lld:pubmed |
| pubmed-article:20457197 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20457197 | pubmed:articleTitle | Rice seed ER-derived protein body as an efficient delivery vehicle for oral tolerogenic peptides. | lld:pubmed |
| pubmed-article:20457197 | pubmed:affiliation | Transgenic Crop Research and Development Center, National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan. hitakagi@affrc.go.jp | lld:pubmed |
| pubmed-article:20457197 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20457197 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:20457197 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
