| pubmed-article:20439744 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20439744 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:20439744 | lifeskim:mentions | umls-concept:C0016163 | lld:lifeskim |
| pubmed-article:20439744 | lifeskim:mentions | umls-concept:C0043357 | lld:lifeskim |
| pubmed-article:20439744 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:20439744 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:20439744 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:20439744 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:20439744 | pubmed:dateCreated | 2010-5-20 | lld:pubmed |
| pubmed-article:20439744 | pubmed:abstractText | We examined the wavelength dependence of ultraviolet (UV) ra-diation (UVR)-induced melanoma in a Xiphophorus backcross hybrid model previously reported to be susceptible to melanoma induction by ultraviolet A (UVA) and visible light. Whereas ultraviolet B (UVB) irradiation of neonates yielded high frequencies of melanomas in pigmented fish, UVA irradiation resulted in melanoma frequencies that were not significantly different from unirradiated fish. Spontaneous and UV-induced melanoma frequencies correlated with the degree of pigmentation as expected from previous studies, and the histopathology phenotypes of the melanomas were not found in significantly different proportions in UV-treated and -untreated tumor-bearing fish. Our results support the conclusion that a brief early-life exposure to UVB radiation causes melanoma formation in this animal model. These data are consistent with an essential role for direct DNA damage, including cyclobutane dimers and (6-4) photoproducts, in the etiology of melanoma. | lld:pubmed |
| pubmed-article:20439744 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20439744 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20439744 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20439744 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20439744 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20439744 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20439744 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20439744 | pubmed:month | May | lld:pubmed |
| pubmed-article:20439744 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20439744 | pubmed:author | pubmed-author:ThamesHoward... | lld:pubmed |
| pubmed-article:20439744 | pubmed:author | pubmed-author:Gimenez-Conti... | lld:pubmed |
| pubmed-article:20439744 | pubmed:author | pubmed-author:MitchellDavid... | lld:pubmed |
| pubmed-article:20439744 | pubmed:author | pubmed-author:NairnRodney... | lld:pubmed |
| pubmed-article:20439744 | pubmed:author | pubmed-author:GarciaRachelR | lld:pubmed |
| pubmed-article:20439744 | pubmed:author | pubmed-author:TronoDavidD | lld:pubmed |
| pubmed-article:20439744 | pubmed:author | pubmed-author:PanikerLakshm... | lld:pubmed |
| pubmed-article:20439744 | pubmed:author | pubmed-author:FernandezAndr... | lld:pubmed |
| pubmed-article:20439744 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20439744 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:20439744 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20439744 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20439744 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20439744 | pubmed:pagination | 9329-34 | lld:pubmed |
| pubmed-article:20439744 | pubmed:dateRevised | 2010-11-22 | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:meshHeading | pubmed-meshheading:20439744... | lld:pubmed |
| pubmed-article:20439744 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20439744 | pubmed:articleTitle | Ultraviolet A does not induce melanomas in a Xiphophorus hybrid fish model. | lld:pubmed |
| pubmed-article:20439744 | pubmed:affiliation | Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA. dmitchel@mdanderson.org | lld:pubmed |
| pubmed-article:20439744 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20439744 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
