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pubmed-article:20405897pubmed:abstractTextA novel palladium(0)-catalyzed domino cyclization of 2-alkynylaziridines with isocyanates through ring expansion is described. Treatment of N-protected 2-(4-aminobut-1-ynyl)aziridine derivatives with a catalytic amount of Pd(PPh(3))(4) and aryl isocyanates in THF at room temperature affords 4-(4,5-dihydropyrrol-2-yl)imidazolidin-2-one derivatives in good yields. Interestingly, bis-adducts were selectively obtained by use of excess isocyanate (5 equiv) at lower reaction temperature.lld:pubmed
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pubmed-article:20405897pubmed:authorpubmed-author:OhnoHiroakiHlld:pubmed
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pubmed-article:20405897pubmed:articleTitleConstruction of linked nitrogen heterocycles by palladium(0)-catalyzed intramolecular domino cyclization of 2-alkynylaziridines bearing a 2-aminoethyl group via ring expansion with isocyanate.lld:pubmed
pubmed-article:20405897pubmed:affiliationGraduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.lld:pubmed
pubmed-article:20405897pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20405897pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed