| pubmed-article:20388540 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20388540 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:20388540 | lifeskim:mentions | umls-concept:C0023473 | lld:lifeskim |
| pubmed-article:20388540 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:20388540 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:20388540 | lifeskim:mentions | umls-concept:C0308269 | lld:lifeskim |
| pubmed-article:20388540 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:20388540 | lifeskim:mentions | umls-concept:C0324024 | lld:lifeskim |
| pubmed-article:20388540 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20388540 | pubmed:dateCreated | 2010-5-24 | lld:pubmed |
| pubmed-article:20388540 | pubmed:abstractText | Slug, a Snail-related zinc-finger transcription factor implicated in the increased motility of mesenchymal cells during embryonic development and progression of cancer cells towards an invasive phenotype, plays a specific and critical role in the pathogenesis of Bcr-Abl-associated leukemias. Here we report that Slug over-expression associated with Bcr-Abl is conditional upon the tyrosine kinase (TK) activity of 210 fusion protein. Slug over-expression is driven by transcriptional events eventually integrated by post-transcriptional mechanisms leading to protein stabilization and is at least partly regulated by the ERK1/2 mitogen-activated protein kinase (MAPK). It contributes to apoptosis resistance of leukemic progenitors through the repression of pro-apoptotic Puma. Moreover, Slug is a component of leukemic progenitor resistance to imatinib mesylate (IM) driven by Bcr-Abl point mutations and, in particular, by T315I. Slug over-expression associated with p210 Bcr-Abl TK either in the wild type (wt) or mutated conformation results in a significant reduction of E-cadherin, the substrate of Beta catenin at cell membranes. In conclusion, our results suggest that Slug has a central role in a complex network involved in prolonged survival and IM resistance of CML progenitors. | lld:pubmed |
| pubmed-article:20388540 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20388540 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20388540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20388540 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20388540 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20388540 | pubmed:issn | 1873-3913 | lld:pubmed |
| pubmed-article:20388540 | pubmed:author | pubmed-author:BarbieriEnzaE | lld:pubmed |
| pubmed-article:20388540 | pubmed:author | pubmed-author:SantucciMaria... | lld:pubmed |
| pubmed-article:20388540 | pubmed:author | pubmed-author:ManciniManuel... | lld:pubmed |
| pubmed-article:20388540 | pubmed:author | pubmed-author:IacobucciIlar... | lld:pubmed |
| pubmed-article:20388540 | pubmed:author | pubmed-author:SalvestriniVa... | lld:pubmed |
| pubmed-article:20388540 | pubmed:author | pubmed-author:PettaSaraS | lld:pubmed |
| pubmed-article:20388540 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20388540 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:20388540 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20388540 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20388540 | pubmed:pagination | 1247-53 | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:meshHeading | pubmed-meshheading:20388540... | lld:pubmed |
| pubmed-article:20388540 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20388540 | pubmed:articleTitle | Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cells. | lld:pubmed |
| pubmed-article:20388540 | pubmed:affiliation | Department of Hematology and Oncology Lorenzo e Ariosto Seràgnoli, University of Bologna-Medical School, Via Massarenti 9, 40138-Bologna, Italy. mancini_manu@yahoo.com <mancini_manu@yahoo.com> | lld:pubmed |
| pubmed-article:20388540 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20388540 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20388540 | lld:pubmed |
