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pubmed-article:20360864pubmed:abstractTextMatrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the MMP3 gene and that this polymorphism is located within a cis-element that interacts with the transcription factor NFkappaB. In the present study, we sought to investigate whether MMP3 and NFkappaB were co-localized in atherosclerotic lesions and whether NFkappaB had differential effects on the two alleles of the MMP3 5A/6A polymorphism.lld:pubmed
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pubmed-article:20360864pubmed:articleTitleAllele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.lld:pubmed
pubmed-article:20360864pubmed:affiliationWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.lld:pubmed
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