| pubmed-article:20349122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20349122 | lifeskim:mentions | umls-concept:C1136170 | lld:lifeskim |
| pubmed-article:20349122 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:20349122 | lifeskim:mentions | umls-concept:C1826433 | lld:lifeskim |
| pubmed-article:20349122 | lifeskim:mentions | umls-concept:C1829683 | lld:lifeskim |
| pubmed-article:20349122 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:20349122 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20349122 | pubmed:dateCreated | 2010-7-9 | lld:pubmed |
| pubmed-article:20349122 | pubmed:abstractText | INTRODUCTION: Cytokine production by innate immune cells is initiated by signaling downstream of pattern recognition receptors, including Toll-like receptors. DISCUSSION: A subset of cytokines, including IL-1beta and IL-18, require post-translational proteolysis before secretion, which provides a second mechanism of regulation. This proteolysis is dependent upon caspase 1, which is activated by Nod-like receptor (NLR) signaling. NLRC4 (previously named Ipaf) activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems (T3SS and T4SS). NLRC4 recognizes T3SS/T4SS in two ways: indirectly by detecting flagellin, and directly by detecting the T3SS rod protein. Both flagellin and rod protein are unintentionally delivered to the mammalian cytosol by the bacterium through the T3SS. | lld:pubmed |
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| pubmed-article:20349122 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20349122 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20349122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20349122 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20349122 | pubmed:issn | 1573-2592 | lld:pubmed |
| pubmed-article:20349122 | pubmed:author | pubmed-author:MiaoEdward... | lld:pubmed |
| pubmed-article:20349122 | pubmed:author | pubmed-author:WarrenSarah... | lld:pubmed |
| pubmed-article:20349122 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20349122 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:20349122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20349122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20349122 | pubmed:pagination | 502-6 | lld:pubmed |
| pubmed-article:20349122 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:20349122 | pubmed:meshHeading | pubmed-meshheading:20349122... | lld:pubmed |
| pubmed-article:20349122 | pubmed:meshHeading | pubmed-meshheading:20349122... | lld:pubmed |
| pubmed-article:20349122 | pubmed:meshHeading | pubmed-meshheading:20349122... | lld:pubmed |
| pubmed-article:20349122 | pubmed:meshHeading | pubmed-meshheading:20349122... | lld:pubmed |
| pubmed-article:20349122 | pubmed:meshHeading | pubmed-meshheading:20349122... | lld:pubmed |
| pubmed-article:20349122 | pubmed:meshHeading | pubmed-meshheading:20349122... | lld:pubmed |
| pubmed-article:20349122 | pubmed:meshHeading | pubmed-meshheading:20349122... | lld:pubmed |
| pubmed-article:20349122 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20349122 | pubmed:articleTitle | Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome. | lld:pubmed |
| pubmed-article:20349122 | pubmed:affiliation | Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA. emiao@systemsbiology.org | lld:pubmed |
| pubmed-article:20349122 | pubmed:publicationType | Journal Article | lld:pubmed |
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