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pubmed-article:20347304pubmed:abstractTextA novel series of arylindenopyrimidines were identified as A(2A) and A(1) receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson's disease when dosed orally.lld:pubmed
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pubmed-article:20347304pubmed:copyrightInfo2010 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:20347304pubmed:articleTitleMethylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.lld:pubmed
pubmed-article:20347304pubmed:affiliationJohnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, PO Box 776, Spring House, PA 19477, United States. bshook@its.jnj.comlld:pubmed
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