| pubmed-article:2032474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C0740294 | lld:lifeskim |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C0007257 | lld:lifeskim |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C0028210 | lld:lifeskim |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C0012222 | lld:lifeskim |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2032474 | lifeskim:mentions | umls-concept:C0060696 | lld:lifeskim |
| pubmed-article:2032474 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2032474 | pubmed:dateCreated | 1991-6-24 | lld:pubmed |
| pubmed-article:2032474 | pubmed:abstractText | In order to assess the apparent diffusion coefficient of two nitrosoureas (carmustine and fotemustine) in the brain, a model of planar diffusion was used in the rat brain and in rat and human brain biopsies. Drugs were deposed on the brain surface at a constant concentration for 30 min. At the end of the diffusion time, the concentration gradient was determined with microelectrodes using voltammetry at 5 different depths in the extracellular space of the gray matter (0-304 microns). Voltammetry with microelectrodes measured quantitatively intact drug in the brain extracellular space (CV 4% for the 2 drugs) in the range studied. The same procedure was used for human and rat brain biopsies which were held in a small cup. The apparent diffusion coefficients in living animals were 0.49 x 10(-6) cm2.s-1 for carmustine and 0.23 x 10(-6) cm2.s-1 for fotemustine; in human biopsies, they were 0.84 x 10(-6) cm2.s-1 for carmustine and 0.37 x 10(-6) cm2.s-1 for fotemustine. Significant differences in the apparent diffusion coefficients of the drugs were accounted for by the fact that the intracellular penetration of fotemustine was better than that of carmustine. | lld:pubmed |
| pubmed-article:2032474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2032474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032474 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2032474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2032474 | pubmed:issn | 0009-3157 | lld:pubmed |
| pubmed-article:2032474 | pubmed:author | pubmed-author:HenzelDD | lld:pubmed |
| pubmed-article:2032474 | pubmed:author | pubmed-author:MeulemansAA | lld:pubmed |
| pubmed-article:2032474 | pubmed:author | pubmed-author:RobineDD | lld:pubmed |
| pubmed-article:2032474 | pubmed:author | pubmed-author:GirouxBB | lld:pubmed |
| pubmed-article:2032474 | pubmed:author | pubmed-author:HannounPP | lld:pubmed |
| pubmed-article:2032474 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2032474 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:2032474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2032474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2032474 | pubmed:pagination | 86-92 | lld:pubmed |
| pubmed-article:2032474 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
| pubmed-article:2032474 | pubmed:meshHeading | pubmed-meshheading:2032474-... | lld:pubmed |
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| pubmed-article:2032474 | pubmed:meshHeading | pubmed-meshheading:2032474-... | lld:pubmed |
| pubmed-article:2032474 | pubmed:meshHeading | pubmed-meshheading:2032474-... | lld:pubmed |
| pubmed-article:2032474 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2032474 | pubmed:articleTitle | Comparative diffusion study of two nitrosoureas: carmustine and fotemustine in normal rat brain, human and rat brain biopsies. | lld:pubmed |
| pubmed-article:2032474 | pubmed:affiliation | Faculté de Médecine Xavier-Bichat, Paris, France. | lld:pubmed |
| pubmed-article:2032474 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2032474 | pubmed:publicationType | Comparative Study | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2032474 | lld:pubmed |
