Linked Life Data

20301892

Source:http://linkedlifedata.com/resource/pubmed/id/20301892

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pubmed-article:20301892pubmed:abstractTextInitiation and progression of laryngeal cancer is associated with tobacco smoking and abusing of strong alcoholic beverages. A significance of genetic factor, although not defined sufficiently yet has been raised as well. The studies were focused on an influence of AHR gene polymorphism on survival of squamous cell carcinoma laryngeal subjects. The study material was 65 archival DNA samples analyzed by RLP-PCR. The samples varying with electrophoretic mobility were DNA sequenced. In the study group 9 heterozygotic variants Arg554Lys (codon 554) were detected. One case was a carrier of two other mutations in codon: 490 (1468 A > G) and 570 (1708 G > A). Survival time, metastasis and occurrence of second primary tumors were compared in carriers of wild type and Arg554Lys variant AHR. Preliminary results indicate for a necessity of further studies as until now the study group is too small to find a conclusive association.lld:pubmed
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pubmed-article:20301892pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:20301892pubmed:articleTitle[Significance of Arg554Lys AHR gene polymorhism an survival of in squamous cell carcinoma laryngeal cancer in relation to tobacco smoking--preliminary study].lld:pubmed
pubmed-article:20301892pubmed:affiliationZak?ad Mutagenezy Srodowiskowej, Instytut Genetyki Cz?owieka PAN, Pozna?. madlen.arndt@wp.pllld:pubmed
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