pubmed-article:20233318 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C0037047 | lld:lifeskim |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C0011429 | lld:lifeskim |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C0024687 | lld:lifeskim |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:20233318 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:20233318 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:20233318 | pubmed:dateCreated | 2010-7-13 | lld:pubmed |
pubmed-article:20233318 | pubmed:abstractText | Human X-linked hypophosphatemia (XLH) and its murine homologue, Hyp are caused by inactivating mutations in PHEX gene. The protein encoded by PHEX gene is an endopeptidase whose physiological substrate(s) has not been identified. Dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP), two members of the Small Integrin-Binding LIgand, N-linked Glycoprotein (SIBLING) family are proteolytically processed. It has been speculated that PHEX endopeptidase may be responsible for the proteolytic cleavage of DMP1 and DSPP. To test this hypothesis and to analyse the distribution of SIBLING proteins in the predentin/dentin complex and mandible of Hyp mice, we compared the expression of four SIBLING proteins, DMP1, DSPP, bone sialoprotein (BSP) and osteopontin (OPN) between Hyp and wild-type mice. | lld:pubmed |
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pubmed-article:20233318 | pubmed:language | eng | lld:pubmed |
pubmed-article:20233318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20233318 | pubmed:citationSubset | D | lld:pubmed |
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pubmed-article:20233318 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:20233318 | pubmed:month | Jul | lld:pubmed |
pubmed-article:20233318 | pubmed:issn | 1601-0825 | lld:pubmed |
pubmed-article:20233318 | pubmed:author | pubmed-author:YUH IHI | lld:pubmed |