| pubmed-article:20194741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20194741 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20194741 | lifeskim:mentions | umls-concept:C0022131 | lld:lifeskim |
| pubmed-article:20194741 | lifeskim:mentions | umls-concept:C0271650 | lld:lifeskim |
| pubmed-article:20194741 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:20194741 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:20194741 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:20194741 | pubmed:dateCreated | 2010-3-22 | lld:pubmed |
| pubmed-article:20194741 | pubmed:abstractText | Glucose homeostasis is critically dependent on insulin release from pancreatic beta-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (V(m)) and the cytosolic calcium level ([Ca(2+)](cyt)). We propose that TRPM5, a Ca(2+)-activated monovalent cation channel, is a positive regulator of glucose-induced insulin release. Immunofluorescence revealed expression of TRPM5 in pancreatic islets. A Ca(2+)-activated nonselective cation current with TRPM5-like properties is significantly reduced in Trpm5(-/-) cells. Ca(2+)-imaging and electrophysiological analysis show that glucose-induced oscillations of V(m) and [Ca(2+)](cyt) have on average a reduced frequency in Trpm5(-/-) islets, specifically due to a lack of fast oscillations. As a consequence, glucose-induced insulin release from Trpm5(-/-) pancreatic islets is significantly reduced, resulting in an impaired glucose tolerance in Trpm5(-/-) mice. | lld:pubmed |
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| pubmed-article:20194741 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20194741 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194741 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20194741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20194741 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20194741 | pubmed:issn | 1091-6490 | lld:pubmed |
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| pubmed-article:20194741 | pubmed:author | pubmed-author:NiliusBerndB | lld:pubmed |
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| pubmed-article:20194741 | pubmed:author | pubmed-author:VoetsThomasT | lld:pubmed |
| pubmed-article:20194741 | pubmed:author | pubmed-author:SegalAndreiA | lld:pubmed |
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| pubmed-article:20194741 | pubmed:author | pubmed-author:TalaveraKarel... | lld:pubmed |
| pubmed-article:20194741 | pubmed:author | pubmed-author:KokrashviliZa... | lld:pubmed |
| pubmed-article:20194741 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:20194741 | pubmed:author | pubmed-author:LemaireKatlee... | lld:pubmed |
| pubmed-article:20194741 | pubmed:author | pubmed-author:QuintensRoelR | lld:pubmed |
| pubmed-article:20194741 | pubmed:author | pubmed-author:ColsoulBarbar... | lld:pubmed |
| pubmed-article:20194741 | pubmed:author | pubmed-author:SchraenenAnic... | lld:pubmed |
| pubmed-article:20194741 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20194741 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:20194741 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20194741 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20194741 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20194741 | pubmed:pagination | 5208-13 | lld:pubmed |
| pubmed-article:20194741 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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