Linked Life Data

20172652

Source:http://linkedlifedata.com/resource/pubmed/id/20172652

Statements in which the resource exists.
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pubmed-article:20172652pubmed:abstractTextThe ethics of placebo research have been of paramount concern since the discovery of the phenomenon. To address these ethical concerns, Miller and colleagues (PLoS Med 2005 Sep;2(9):e262, 0853-0859) propose an alternate approach to placebo research, called "authorized deception", in which participants are alerted of the use of deception in the research prior to study enrollment and thus knowingly permit its use if they decide to participate. The present study sought to investigate the authorized deception methodology in experimentally induced placebo analgesia. The participants were randomly assigned to an authorized deception or non-authorized deception group. A commonly used protocol was employed wherein heat pain stimulation was surreptitiously lowered following the application of a placebo cream during a series of conditioning trials and the magnitude of the placebo effect was subsequently assessed in test trials for which the stimulus intensity was the same for both the placebo and control creams. Authorized deception did not have any negative impact on the magnitude of the placebo effect, recruitment and retention of participants, nor did it result in any significant psychological harm. The majority of participants who received this form of consent preferred it to the traditional approach in which the participants are not alerted to the presence of deception. These findings suggest that the use of authorized deception is a viable and ethically preferable alternative consent process for laboratory-based studies on placebo analgesia. Further studies are needed to examine the effect of authorized deception in clinical trials and other placebo research within a clinical setting.lld:pubmed
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pubmed-article:20172652pubmed:authorpubmed-author:KatzJoelJlld:pubmed
pubmed-article:20172652pubmed:authorpubmed-author:MartinAndrea...lld:pubmed
pubmed-article:20172652pubmed:copyrightInfoCopyright 2009 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.lld:pubmed
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pubmed-article:20172652pubmed:pagination208-15lld:pubmed
pubmed-article:20172652pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:20172652pubmed:articleTitleInclusion of authorized deception in the informed consent process does not affect the magnitude of the placebo effect for experimentally induced pain.lld:pubmed
pubmed-article:20172652pubmed:affiliationDepartment of Psychology, Behavioral Sciences Building, York University, 4700 Keele Street, Toronto, Ont., Canada M3J 1P3. amartin@yorku.calld:pubmed
pubmed-article:20172652pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20172652pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed