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pubmed-article:20170541pubmed:abstractTextThe BMI1 oncogene is overexpressed in several human malignancies including gastric cancer. In addition to BMI1, mammalian cells also express Mel-18, which is closely related to BMI1. We have reported that Mel-18 functions as a potential tumor suppressor by repressing the expression of BMI1 and consequent downregulation of activated AKT in breast cancer cells. However, the mechanisms of BMI1 overexpression and the role of Mel-18 in other cancers are still not clear. The purpose of this study is to investigate the role of BMI1 and Mel-18 in gastric cancer.lld:pubmed
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pubmed-article:20170541pubmed:articleTitleBMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.lld:pubmed
pubmed-article:20170541pubmed:affiliationDepartment of Medical Oncology, Cancer Hospital of Fudan University, 270 Dong An Road, Shanghai 200032, China.lld:pubmed
pubmed-article:20170541pubmed:publicationTypeJournal Articlelld:pubmed
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