| pubmed-article:20157004 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20157004 | lifeskim:mentions | umls-concept:C0004810 | lld:lifeskim |
| pubmed-article:20157004 | lifeskim:mentions | umls-concept:C0016832 | lld:lifeskim |
| pubmed-article:20157004 | lifeskim:mentions | umls-concept:C1692873 | lld:lifeskim |
| pubmed-article:20157004 | lifeskim:mentions | umls-concept:C0010416 | lld:lifeskim |
| pubmed-article:20157004 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:20157004 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20157004 | pubmed:dateCreated | 2010-6-2 | lld:pubmed |
| pubmed-article:20157004 | pubmed:abstractText | Cryptococcus neoformans is a basidiomycete fungus that is found worldwide and causes disease in humans and animal species. The fungus grows asexually as a budding yeast. Under laboratory conditions it is capable of sexual reproduction between two mating types. After cell fusion a dikaryotic filament develops, at the tip of which a basidium gives rise to four chains of basidiospores. Because the chains each comprise 10-30 spores, rather than single spores, the analysis of individual meiotic events has not been attempted in C. neoformans in the style of tetrad analyses performed in other fungal species. Here, the basidiospores from >100 basidia were micromanipulated and the resultant >2500 progeny analyzed for three genetic markers to understand the sexual process in this fungus, leading to four observations: (i) Marker segregation provides genetic evidence for a single meiotic event within the basidium followed by multiple rounds of mitosis. (ii) Using each basidium as an unordered tetrad, the ADE2 and URA5 genes are linked to their centromeres, consistent with adjacent genomic regions rich in repetitive elements predicted to comprise Cryptococcus centromeres. (iii) Lack of germination of basidiospores is attributed to aneuploidy, rather than dormancy. (iv) Analysis of basidiospores derived from single chains demonstrates that each chain can contain different genotypes. This mechanism of sexual spore production would benefit the species with a high rate of dispersal and at the same time aid in simultaneous dissemination of both mating types to new locations in the environment. | lld:pubmed |
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| pubmed-article:20157004 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20157004 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20157004 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20157004 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20157004 | pubmed:month | May | lld:pubmed |
| pubmed-article:20157004 | pubmed:issn | 1943-2631 | lld:pubmed |
| pubmed-article:20157004 | pubmed:author | pubmed-author:IdnurmAlexand... | lld:pubmed |
| pubmed-article:20157004 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20157004 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:20157004 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20157004 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20157004 | pubmed:pagination | 153-63 | lld:pubmed |
| pubmed-article:20157004 | pubmed:dateRevised | 2011-11-4 | lld:pubmed |
| pubmed-article:20157004 | pubmed:meshHeading | pubmed-meshheading:20157004... | lld:pubmed |
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| pubmed-article:20157004 | pubmed:meshHeading | pubmed-meshheading:20157004... | lld:pubmed |
| pubmed-article:20157004 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20157004 | pubmed:articleTitle | A tetrad analysis of the basidiomycete fungus Cryptococcus neoformans. | lld:pubmed |
| pubmed-article:20157004 | pubmed:affiliation | Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA. idnurma@umkc.edu | lld:pubmed |
| pubmed-article:20157004 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20157004 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
