| pubmed-article:20155409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20155409 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:20155409 | lifeskim:mentions | umls-concept:C0023449 | lld:lifeskim |
| pubmed-article:20155409 | lifeskim:mentions | umls-concept:C1257975 | lld:lifeskim |
| pubmed-article:20155409 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:20155409 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20155409 | pubmed:dateCreated | 2010-3-11 | lld:pubmed |
| pubmed-article:20155409 | pubmed:abstractText | Childhood acute lymphoblastic leukemia (ALL) is caused by malignant immature lymphocytes. Even though childhood ALL can be cured in a large number of patients, around 20% of the patients suffer a relapse after chemotherapy. The origin of the relapse is unclear at the present time. Given the high plasticity of cells, we searched for leukemia-associated genetic aberrations and immunoglobulin (IG) gene rearrangements in mesenchymal stem cells (MSC) from childhood B-cell precursor ALL patients. MSC from all ten ALL patients analyzed presented the chromosomal translocations that had been detected in leukemia cells (TEL-AML1, E2A-PBX1, or MLL rearrangement). The proportions of translocation-positive MSC varied between 10% and 54% depending on the patients and the time point of analysis. Leukemia-specific IG gene rearrangements were detected in the MSC from three ALL patients. The detection of leukemia-associated genetic aberrations in MSC indicates a clonal relationship between MSC and leukemia cells and suggests their involvement in the pathogenesis and/or pathophysiology of childhood ALL. | lld:pubmed |
| pubmed-article:20155409 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20155409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20155409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20155409 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20155409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20155409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20155409 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20155409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20155409 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20155409 | pubmed:issn | 1432-1440 | lld:pubmed |
| pubmed-article:20155409 | pubmed:author | pubmed-author:HenzeGünterG | lld:pubmed |
| pubmed-article:20155409 | pubmed:author | pubmed-author:BlankensteinT... | lld:pubmed |
| pubmed-article:20155409 | pubmed:author | pubmed-author:SeegerKarlK | lld:pubmed |
| pubmed-article:20155409 | pubmed:author | pubmed-author:EckertCorneli... | lld:pubmed |
| pubmed-article:20155409 | pubmed:author | pubmed-author:KammertoensTh... | lld:pubmed |
| pubmed-article:20155409 | pubmed:author | pubmed-author:PradaJavierJ | lld:pubmed |
| pubmed-article:20155409 | pubmed:author | pubmed-author:ShalapourShab... | lld:pubmed |
| pubmed-article:20155409 | pubmed:author | pubmed-author:PfauMadlenM | lld:pubmed |
| pubmed-article:20155409 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20155409 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:20155409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20155409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20155409 | pubmed:pagination | 249-65 | lld:pubmed |
| pubmed-article:20155409 | pubmed:dateRevised | 2011-7-8 | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:meshHeading | pubmed-meshheading:20155409... | lld:pubmed |
| pubmed-article:20155409 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20155409 | pubmed:articleTitle | Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia. | lld:pubmed |
| pubmed-article:20155409 | pubmed:affiliation | Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany. Shabnam.shalapour@charite.de | lld:pubmed |
| pubmed-article:20155409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20155409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20155409 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20155409 | lld:pubmed |
