| pubmed-article:20126461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C1332684 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C1420814 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C0552639 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20126461 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:20126461 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20126461 | pubmed:dateCreated | 2010-2-3 | lld:pubmed |
| pubmed-article:20126461 | pubmed:abstractText | TWEAK is a member of the TNF superfamily of cytokines that contribute to kidney tubulointerstitial injury. It has previously been reported that TWEAK induces transient nuclear translocation of RelA and expression of RelA-dependent cytokines in renal tubular cells. Additionally, TWEAK induced long-lasting NFkappaB activation suggestive of engagement of the non-canonical NFkappaB pathway. We now explore TWEAK-induced activation of NFkappaB2 and RelB, as well as expression of CCL21, a T-cell chemotactic factor, in cultured murine tubular epithelial cells and in healthy kidneys in vivo. In cultured tubular cells, TWEAK and TNFalpha activated different DNA-binding NFkappaB complexes. TWEAK-induced sustained NFkappaB activation was associated with NFkappaB2 p100 processing to p52 via proteasome and nuclear translocation and DNA-binding of p52 and RelB. TWEAK, but not TNFalpha used as control), induced a delayed increase in CCL21a mRNA (3.5+/-1.22-fold over control) and CCL21 protein (2.5+/-0.8-fold over control), which was prevented by inhibition of the proteasome, or siRNA targeting of NIK or RelB, but not by RelA inhibition with parthenolide. A second NFkappaB2-dependent chemokine, CCL19, was upregulates by TWEAK, but not by TNFalpha. However, both cytokines promoted chemokine RANTES expression (3-fold mRNA at 24 h). In vivo, TWEAK induced nuclear NFkappaB2 and RelB translocation and CCL21a mRNA (1.5+/-0.3-fold over control) and CCL21 protein (1.6+/-0.5-fold over control) expression in normal kidney. Increased tubular nuclear RelB and tubular CCL21 expression in acute kidney injury were decreased by neutralization (2+/-0.9 vs 1.3+/-0.6-fold over healthy control) or deficiency of TWEAK (2+/-0.9 vs 0.8+/-0.6-fold over healthy control). Moreover, anti-TWEAK treatment prevented the recruitment of T cells to the kidney in this model (4.1+/-1.4 vs 1.8+/-1-fold over healthy control). Our results thus identify TWEAK as a regulator of non-canonical NFkappaB activation and CCL21 expression in tubular cells thus promoting lymphocyte recruitment to the kidney during acute injury. | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20126461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20126461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20126461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20126461 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:SelgasRafaelR | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:JakubowskiAni... | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:EgidoJesúsJ | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:Ruiz-OrtegaMa... | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:OrtizAlbertoA | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:Blanco-ColioL... | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:JustoPilarP | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:SanzAna BAB | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:Sanchez-NiñoM... | lld:pubmed |
| pubmed-article:20126461 | pubmed:author | pubmed-author:IzquierdoMari... | lld:pubmed |
| pubmed-article:20126461 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20126461 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:20126461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20126461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20126461 | pubmed:pagination | e8955 | lld:pubmed |
| pubmed-article:20126461 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:meshHeading | pubmed-meshheading:20126461... | lld:pubmed |
| pubmed-article:20126461 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20126461 | pubmed:articleTitle | TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21. | lld:pubmed |
| pubmed-article:20126461 | pubmed:affiliation | Servicio de Nefrologia, Fundación para la Investigación Biomédica del Hospital Universitario La Paz, Madrid, Spain. | lld:pubmed |
| pubmed-article:20126461 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20126461 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:21944 | entrezgene:pubmed | pubmed-article:20126461 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20126461 | lld:entrezgene |
