| pubmed-article:20122401 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20122401 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:20122401 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:20122401 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:20122401 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:20122401 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20122401 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:20122401 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20122401 | pubmed:dateCreated | 2010-2-3 | lld:pubmed |
| pubmed-article:20122401 | pubmed:abstractText | Wnt family members play diverse roles in development and disease. Noncanonical Wnt ligands can inhibit canonical Wnt signaling depending on the cellular context; however, the underlying mechanism of this antagonism remains poorly understood. Here we identify a specific mechanism of orphan nuclear receptor RORalpha-mediated inhibition of canonical Wnt signaling in colon cancer. Wnt5a/PKCalpha-dependent phosphorylation on serine residue 35 of RORalpha is crucial to link RORalpha to Wnt/beta-catenin signaling, which exerts inhibitory function of the expression of Wnt/beta-catenin target genes. Intriguingly, there is a significant correlation of reduction of RORalpha phosphorylation in colorectal tumor cases compared to their normal counterpart, providing the clinical relevance of the findings. Our data provide evidence for a role of RORalpha, functioning at the crossroads between the canonical and the noncanonical Wnt signaling pathways, in mediating transrepression of the Wnt/beta-catenin target genes, thereby providing new approaches for the development of therapeutic agents for human cancers. | lld:pubmed |
| pubmed-article:20122401 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122401 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122401 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20122401 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122401 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20122401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122401 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122401 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20122401 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20122401 | pubmed:issn | 1097-4164 | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:KimKeun IlKI | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:KimJi-YoungJY | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:RosenfeldMich... | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:SeoSang-BeomS... | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:BaekSung... | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:KimJung HwaJH | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:LeeJi MinJM | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:LeeJason SJS | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:KimHyunkyungH | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:KimHogeunH | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:KimIk SooIS | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:LeeHannaH | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:JeongJiyeongJ | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:KimKyeongkyuK | lld:pubmed |
| pubmed-article:20122401 | pubmed:author | pubmed-author:YimHwa... | lld:pubmed |
| pubmed-article:20122401 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20122401 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20122401 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:20122401 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:20122401 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20122401 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20122401 | pubmed:pagination | 183-95 | lld:pubmed |
| pubmed-article:20122401 | pubmed:dateRevised | 2010-12-17 | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:meshHeading | pubmed-meshheading:20122401... | lld:pubmed |
| pubmed-article:20122401 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20122401 | pubmed:articleTitle | RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. | lld:pubmed |
| pubmed-article:20122401 | pubmed:affiliation | Department of Biological Sciences, Creative Research Initiative Center for Chromatin Dynamics, Seoul National University, Seoul 151-742, South Korea. | lld:pubmed |
| pubmed-article:20122401 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20122401 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:6095 | entrezgene:pubmed | pubmed-article:20122401 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20122401 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20122401 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20122401 | lld:pubmed |
