| pubmed-article:20110445 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C1321301 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0033362 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:20110445 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:20110445 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20110445 | pubmed:dateCreated | 2010-5-3 | lld:pubmed |
| pubmed-article:20110445 | pubmed:abstractText | Proinsulin is a major diabetes-associated autoantigen. APL have been shown to manipulate the immune response of T cells. Here, we generated a lysosomal protease-resistant proinsulin 74-90-derived APL using a CS-directed amino acid modification approach. These prAPL activated TGF-beta 1 secretion in proinsulin-reactive T cells from PBMC of patients with T1D. We provide evidence that proinsulin-derived prAPL modulate the cytokine signature of proinsulin-reactive T cells at a micromolar range by increasing anti-inflammatory cytokines, including TGF-beta 1. Thus, the use of prAPL is a promising tool to mitigate autoaggressive T cells. | lld:pubmed |
| pubmed-article:20110445 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20110445 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20110445 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20110445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20110445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20110445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20110445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20110445 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20110445 | pubmed:month | May | lld:pubmed |
| pubmed-article:20110445 | pubmed:issn | 1938-3673 | lld:pubmed |
| pubmed-article:20110445 | pubmed:author | pubmed-author:KalbacherHube... | lld:pubmed |
| pubmed-article:20110445 | pubmed:author | pubmed-author:BoehmBernhard... | lld:pubmed |
| pubmed-article:20110445 | pubmed:author | pubmed-author:RosingerSilke... | lld:pubmed |
| pubmed-article:20110445 | pubmed:author | pubmed-author:BursterTimoT | lld:pubmed |
| pubmed-article:20110445 | pubmed:author | pubmed-author:SpyrantisAndr... | lld:pubmed |
| pubmed-article:20110445 | pubmed:author | pubmed-author:ZouFangF | lld:pubmed |
| pubmed-article:20110445 | pubmed:author | pubmed-author:PaleschDavidD | lld:pubmed |
| pubmed-article:20110445 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:20110445 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20110445 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:20110445 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20110445 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20110445 | pubmed:pagination | 943-8 | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:meshHeading | pubmed-meshheading:20110445... | lld:pubmed |
| pubmed-article:20110445 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20110445 | pubmed:articleTitle | A proinsulin 74-90-derived protease-resistant, altered peptide ligand increases TGF-beta 1 secretion in PBMC from patients with type 1 diabetes mellitus. | lld:pubmed |
| pubmed-article:20110445 | pubmed:affiliation | Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Medical Center Ulm and Center of Excellence Metabolic Disorders, Baden-Württemberg, Ulm, Germany. | lld:pubmed |
| pubmed-article:20110445 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20110445 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
