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pubmed-article:20105326pubmed:abstractTextThe epidermal growth factor receptor (Egfr) with its numerous ligands has fundamental roles in development, cell differentiation and physiology. Dysfunction of the receptor-ligand system contributes to many human malignancies. Consistent with such various tasks, the Egfr gene family has expanded during vertebrate evolution as a consequence of several rounds of whole genome duplication. Of particular interest is the effect of the fish-specific whole genome duplication (FSGD) on the ligand-receptor system, as it has supplied this largest group of vertebrates with additional opportunities for sub- and/or neofunctionalization in this signaling system.lld:pubmed
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pubmed-article:20105326pubmed:authorpubmed-author:SchartlManfre...lld:pubmed
pubmed-article:20105326pubmed:authorpubmed-author:WalterRonald...lld:pubmed
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pubmed-article:20105326pubmed:articleTitleLineage-specific co-evolution of the Egf receptor/ligand signaling system.lld:pubmed
pubmed-article:20105326pubmed:affiliationDepartment of Physiological Chemistry I, Biocenter, University of Würzburg, Würzburg, Germany. phch1@biozentrum.uni-wuerzburg.de.lld:pubmed
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