| pubmed-article:20093405 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C0020094 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C2826170 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:20093405 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:20093405 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:20093405 | pubmed:dateCreated | 2010-3-26 | lld:pubmed |
| pubmed-article:20093405 | pubmed:abstractText | Human T-cell leukemia virus type I (HTLV-I)-associated malignancies are seen in a small percentage of infected persons. Although in vitro immortalization by HTLV-I virus is very efficient, we report that Tax has poor oncogenic activity in human primary T cells and that immortalization by Tax is rare. Sustained telomerase activity represents one of the oncogenic steps required for Tax-mediated immortalization. Tax expression was required for the growth of primary T cells, but was not sufficient to propel T cells into cell cycle in the absence of exogenous interleukin-2 (IL-2). Tax was sufficient to activate the phosphoinositide-3 kinase (PI3K)/Akt pathway as shown by down regulation of Src homology phosphatase-1 and increased phosphorylation of Akt. We also found disruption of putative tumor suppressors IL-16 and translocated promoter region (TPR) in Tax-immortalized and HTLV-I-transformed cell lines. Our results confirmed previous observations that Tax activates the anaphase-promoting complex. However, Tax did not affect the mitotic spindle checkpoint, which was also functional in HTLV-I-transformed cells. These data provide a better understanding of Tax functions in human T cells, and highlight the limitations of Tax, suggesting that other viral proteins are key to T-cell transformation and development of adult T-cell leukemia. | lld:pubmed |
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| pubmed-article:20093405 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20093405 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20093405 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:20093405 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20093405 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20093405 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:20093405 | pubmed:author | pubmed-author:YuanYaoY | lld:pubmed |
| pubmed-article:20093405 | pubmed:author | pubmed-author:NicotChristop... | lld:pubmed |
| pubmed-article:20093405 | pubmed:author | pubmed-author:BellonMarciaM | lld:pubmed |
| pubmed-article:20093405 | pubmed:author | pubmed-author:BaydounHicham... | lld:pubmed |
| pubmed-article:20093405 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20093405 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:20093405 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:20093405 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20093405 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20093405 | pubmed:pagination | 2441-8 | lld:pubmed |
| pubmed-article:20093405 | pubmed:dateRevised | 2011-7-27 | lld:pubmed |
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| pubmed-article:20093405 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20093405 | pubmed:articleTitle | HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes. | lld:pubmed |
| pubmed-article:20093405 | pubmed:affiliation | University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Center for Viral Oncology, KU Cancer Center, Kansas City, KS 66160, USA. | lld:pubmed |
| pubmed-article:20093405 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20093405 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:1491938 | entrezgene:pubmed | pubmed-article:20093405 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20093405 | lld:entrezgene |
