| pubmed-article:20087405 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20087405 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:20087405 | lifeskim:mentions | umls-concept:C1869116 | lld:lifeskim |
| pubmed-article:20087405 | lifeskim:mentions | umls-concept:C2681936 | lld:lifeskim |
| pubmed-article:20087405 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20087405 | lifeskim:mentions | umls-concept:C1420063 | lld:lifeskim |
| pubmed-article:20087405 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:20087405 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20087405 | pubmed:dateCreated | 2010-5-21 | lld:pubmed |
| pubmed-article:20087405 | pubmed:abstractText | Sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) promotes the apoptosis of eosinophils and inhibits FcvarepsilonRI-dependent mediator release from mast cells. We investigated the genetic association between sequence variants in Siglec-8 and diagnosis of asthma, total levels of serum IgE (tIgE), and diagnosis of eosinophilic esophagitis (EE) in diverse populations. The effect of sequence variants on Siglec-8 glycan ligand-binding activity was also examined. Significant association with asthma was observed for SNP rs36498 (odds ratios (OR), 0.69, P=8.8 x 10(-5)) among African Americans and for SNP rs10409962 (Ser/Pro) in the Japanese population (OR, 0.69, P=0.019). Supporting this finding, we observed association between SNP rs36498 and current asthma among Brazilian families (P=0.013). Significant association with tIgE was observed for SNP rs6509541 among African Americans (P=0.016), and replicated among the Brazilian families (P=0.02). In contrast, no association was observed with EE in Caucasians. By using a synthetic polymer decorated with 6'-sulfo-sLe(x), a known Siglec-8 glycan ligand, we did not find any differences between the ligand-binding activity of HEK293 cells stably transfected with the rs10409962 risk allele or the WT allele. However, our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma. | lld:pubmed |
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| pubmed-article:20087405 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20087405 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20087405 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20087405 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20087405 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20087405 | pubmed:issn | 1476-5438 | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:BochnerBruce... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:RothenbergMar... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:HudsonSherry... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:NishimuraMasa... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:SuSong-NanSN | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:AraujoMaria... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:BarnesKathlee... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:ShimizuKenich... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:HizawaNobuyuk... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:KonnoSatoshiS | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:ZimmermannNiv... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:MathiasRasika... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:ZhouLin-FuLF | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:CruzAlvaro... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:GaoPei-SongPS | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:GrantAudrey... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:RafaelsNichol... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:PonteEduardo... | lld:pubmed |
| pubmed-article:20087405 | pubmed:author | pubmed-author:BeatyTerry... | lld:pubmed |
| pubmed-article:20087405 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20087405 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:20087405 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20087405 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20087405 | pubmed:pagination | 713-9 | lld:pubmed |
| pubmed-article:20087405 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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