| pubmed-article:20081197 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20081197 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:20081197 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:20081197 | lifeskim:mentions | umls-concept:C0011503 | lld:lifeskim |
| pubmed-article:20081197 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:20081197 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:20081197 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:20081197 | pubmed:dateCreated | 2010-3-15 | lld:pubmed |
| pubmed-article:20081197 | pubmed:abstractText | Myeloperoxidase (MPO) generates reactive halogenating species that can modify DNA. The aim of this study was to investigate the formation of 8-halogenated 2'-deoxyguanosines (8- halo-dGs) during inflammatory events. 8-Bromo-2'-dG (8-BrdG) and 8-chloro-2'-dG (8-CldG) were generated by treatment of MPO with hydrogen peroxide at physiological concentrations of Cl(-) and Br(-). The formation of 8-halo-dGs with other oxidative stress biomarkers in lipopolysaccharide-treated rats was assessed by liquid chromatography tandem mass spectrometry and immunohistochemistry using a novel monoclonal antibody (mAb8B3) to 8-BrdG-conjugated keyhole limpet hemocyanin. The antibody recognized both 8-BrdG and 8-CldG. In the liver of lipopolysaccharide-treated rats, immunostaining for 8-halo-dGs, halogenated tyrosines, and MPO were increased at 8 h, whereas those of 8-oxo-2'-dG (8-OxodG) and 3-nitrotyrosine were increased at 24 h. Urinary excretion of both 8-CldG and 8-BrdG was also observed earlier than those of 8-OxodG and modified tyrosines (3-nitrotyrosine, 3-chlorotyrosine, and 3- bromotyrosine). Moreover, the levels of the 8-halo-dGs in urine from human diabetic patients were 8-fold higher than in healthy subjects (n = 10, healthy and diabetic, p < 0.0001), whereas there was a moderate difference in 8-OxodG between the two groups (p < 0.001). Interestingly, positive mAb8B3 antibody staining was observed in liver tissue from hepatocellular carcinoma patients but not in liver tissue from human cirrhosis patients. These data suggest that 8-halo-dGs may be potential biomarkers of early inflammation. | lld:pubmed |
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| pubmed-article:20081197 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20081197 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20081197 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20081197 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20081197 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:OsawaToshihik... | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:YoshikawaTosh... | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:NishinoHoyoku... | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:ArataniYasuak... | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:MasudaMitsuha... | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:KatoYojiY | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:NaitoYujiY | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:AsahiTakashiT | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:KondoHajimeH | lld:pubmed |
| pubmed-article:20081197 | pubmed:author | pubmed-author:HisakaShinsuk... | lld:pubmed |
| pubmed-article:20081197 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20081197 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:20081197 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:20081197 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20081197 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20081197 | pubmed:pagination | 9282-91 | lld:pubmed |
| pubmed-article:20081197 | pubmed:dateRevised | 2011-7-26 | lld:pubmed |
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