| pubmed-article:20073455 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20073455 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20073455 | lifeskim:mentions | umls-concept:C0013161 | lld:lifeskim |
| pubmed-article:20073455 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:20073455 | lifeskim:mentions | umls-concept:C0920425 | lld:lifeskim |
| pubmed-article:20073455 | lifeskim:mentions | umls-concept:C0025938 | lld:lifeskim |
| pubmed-article:20073455 | lifeskim:mentions | umls-concept:C0522529 | lld:lifeskim |
| pubmed-article:20073455 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20073455 | pubmed:dateCreated | 2010-2-17 | lld:pubmed |
| pubmed-article:20073455 | pubmed:abstractText | Herein, we prepared tumor-targeting peptide (AP peptide; CRKRLDRN) conjugated pH-responsive polymeric micelles (pH-PMs) in cancer therapy by active and pH-responsive tumor targeting delivery systems, simultaneously. The active tumor targeting and tumoral pH-responsive polymeric micelles were prepared by mixing AP peptide conjugated PEG-poly(d,l-lactic acid) block copolymer (AP-PEG-PLA) into the pH-responsive micelles of methyl ether poly(ethylene glycol) (MPEG)-poly(beta-amino ester) (PAE) block copolymer (MPEG-PAE). These mixed amphiphilic block copolymers were self-assembled to form stable AP peptide-conjugated and pH-responsive AP-PEG-PLA/MPEG-PAE micelles (AP-pH-PMs) with an average size of 150 nm. The AP-pH-PMs containing 10 wt % of AP-PEG-PLA showed a sharp pH-dependent micellization/demicellization transition at the tumoral acid pH. Also, they presented the pH-dependent drug release profile at the acidic pH of 6.4. The fluorescence dye, TRITC, encapsulated AP-pH-PMs (TRITC-AP-pH-PMs) presented the higher tumor-specific targeting ability in vitro cancer cell culture system and in vivo tumor-bearing mice, compared to control pH-responsive micelles of MPEG-PAE. For the cancer therapy, the anticancer drug, doxorubicin (DOX), was efficiently encapsulated into the AP-pH-PMs (DOX-AP-pH-PMs) with a higher loading efficiency. DOX-AP-pH-PMs efficiently deliver anticancer drugs in MDA-MB231 human breast tumor-bearing mice, resulted in excellent anticancer therapeutic efficacy, compared to free DOX and DOX encapsulated MEG-PAE micelles, indicating the excellent tumor targeting ability of AP-pH-PMs. Therefore, these tumor-targeting peptide-conjugated and pH-responsive polymeric micelles have great potential application in cancer therapy. | lld:pubmed |
| pubmed-article:20073455 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20073455 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20073455 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20073455 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20073455 | pubmed:issn | 1520-4812 | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:LeeByung-Heon... | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:KwonIck... | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:ParkRang-Woon... | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:KimIn-SanIS | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:LeeDoo SungDS | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:ChoiKuiwonK | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:KimKwangmeyun... | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:KooHeebeomH | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:KimJong HoJH | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:KimMin SangMS | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:BaeSang MunSM | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:WuXiang LanXL | lld:pubmed |
| pubmed-article:20073455 | pubmed:author | pubmed-author:ShinHyeriH | lld:pubmed |
| pubmed-article:20073455 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20073455 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:20073455 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:20073455 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20073455 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20073455 | pubmed:pagination | 208-13 | lld:pubmed |
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| pubmed-article:20073455 | pubmed:meshHeading | pubmed-meshheading:20073455... | lld:pubmed |
| pubmed-article:20073455 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20073455 | pubmed:articleTitle | Tumor-targeting peptide conjugated pH-responsive micelles as a potential drug carrier for cancer therapy. | lld:pubmed |
| pubmed-article:20073455 | pubmed:affiliation | Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, 440-746, Republic of Korea. | lld:pubmed |
| pubmed-article:20073455 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20073455 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20073455 | lld:pubmed |
