| pubmed-article:20059397 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C0021403 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:20059397 | lifeskim:mentions | umls-concept:C1548795 | lld:lifeskim |
| pubmed-article:20059397 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20059397 | pubmed:dateCreated | 2010-2-3 | lld:pubmed |
| pubmed-article:20059397 | pubmed:abstractText | Live-attenuated influenza vaccine (LAIV) prevents significantly more cases of influenza in immune-competent children than the trivalent inactivated vaccine (TIV). We compared the T cell responses to LAIV or TIV in HIV-infected children. IFN-gamma-ELISPOT for the three vaccine-contained influenza strains, two mismatched strains, and phytohemagglutinin (PHA), was performed at 0, 4, and 24 weeks postimmunization in 175 HIV-infected children randomly assigned to LAIV or TIV. The contribution of CD8 T cells to the influenza-specific response (CD8-ELISPOT) was evaluated by CD8-cell depletion. CD8 T cells accounted for > or =87% of the total influenza-ELISPOT. At baseline, total influenza-ELISPOT and CD8-ELISPOT values were similar or higher in TIV compared with LAIV recipients. Four and 24 weeks after TIV, total influenza-ELISPOT and CD8-ELISPOT results were significantly lower than baseline results (p < or = 0.001). Responses to PHA also tended to decrease at 4 weeks after TIV (p = 0.06), but rebounded to baseline levels at 24 weeks. Four weeks after LAIV, total influenza-ELISPOT responses to vaccine-contained strains A H3N2 and B significantly decreased. Other ELISPOT values at 4 weeks and all values at 24 weeks were similar to the baseline values. At 4 and 24 weeks, TIV compared to LAIV administration resulted in a significantly greater decrease in influenza-specific ELISPOT values for vaccine-contained influenza A strains (p < or = 0.02). Responses to PHA also tended to decrease more in TIV recipients (p = 0.07). HIV-infected children immunized with TIV had significant and persistent decreases in ELISPOT responses to influenza. LAIV administration suppressed ELISPOT responses less. The clinical significance of these findings deserves further study. | lld:pubmed |
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| pubmed-article:20059397 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20059397 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20059397 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20059397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20059397 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20059397 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20059397 | pubmed:issn | 1931-8405 | lld:pubmed |
| pubmed-article:20059397 | pubmed:author | pubmed-author:WeinbergAdria... | lld:pubmed |
| pubmed-article:20059397 | pubmed:author | pubmed-author:LevinMyron... | lld:pubmed |
| pubmed-article:20059397 | pubmed:author | pubmed-author:NachmanSharon... | lld:pubmed |
| pubmed-article:20059397 | pubmed:author | pubmed-author:FentonTerence... | lld:pubmed |
| pubmed-article:20059397 | pubmed:author | pubmed-author:ReadJennifer... | lld:pubmed |
| pubmed-article:20059397 | pubmed:author | pubmed-author:Patterson-Bar... | lld:pubmed |
| pubmed-article:20059397 | pubmed:author | pubmed-author:SongLin-YeLY | lld:pubmed |
| pubmed-article:20059397 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20059397 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:20059397 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20059397 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20059397 | pubmed:pagination | 51-9 | lld:pubmed |
| pubmed-article:20059397 | pubmed:dateRevised | 2011-7-19 | lld:pubmed |
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