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pubmed-article:20046518pubmed:abstractTextThe inhibition of phosphodiesterase 5 produces an antinociception through the increase of cyclic guanosine monophosphate (cGMP), and increasing cGMP levels enhance the release of gamma-aminobutyric acid (GABA). Furthermore, this phosphodiesterase 5 plays a pivotal role in the regulation of the vasodilatation associated to cGMP. In this work, we examined the contribution of GABA receptors to the effect of sildenafil, a phosphodiesterase 5 inhibitor, in a neuropathic pain rat, and assessed the hemodynamic effect of sildenafil in normal rats.lld:pubmed
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pubmed-article:20046518pubmed:authorpubmed-author:YoonMyung...lld:pubmed
pubmed-article:20046518pubmed:authorpubmed-author:ChoiJeong...lld:pubmed
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pubmed-article:20046518pubmed:authorpubmed-author:LeeHyung...lld:pubmed
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pubmed-article:20046518pubmed:articleTitleEffect of sildenafil on neuropathic pain and hemodynamics in rats.lld:pubmed
pubmed-article:20046518pubmed:affiliationThe Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam National University, Dong-gu, Gwangju, Korea.lld:pubmed
pubmed-article:20046518pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20046518pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed