| pubmed-article:20033317 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C1442162 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C1710706 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C1550718 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:20033317 | lifeskim:mentions | umls-concept:C1743100 | lld:lifeskim |
| pubmed-article:20033317 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20033317 | pubmed:dateCreated | 2010-1-21 | lld:pubmed |
| pubmed-article:20033317 | pubmed:abstractText | The effects of intracerebroventricular administration of fragment (25-35) of beta-amyloid peptide [Abeta(25-35)] on cell proliferation in the subventricular zone of the dentate gyrus of the hippocampus in adult rats were analyzed. Animals received doses of 15 nmol of pre-aggregated Abeta(25-35) or the Abeta(35-25) control peptide, or solvent (sterile water) into the lateral ventricles. On post-injection days 1-5, rats received intraperitoneal injections of the thymidine analog 5-bromo-2'-deoxyuridine (BrdU). BrdU incorporated into DNA was detected immunohistochemically on frontal brain sections six and 12 days after peptide administration. At six days, the numbers of BrdU-containing cells in the subventricular zone showed no differences between the study groups. At 12 days, the total number of BrdU-positive cells decreased significantly in all study groups. At the same time, the number of labeled cells in rats given Abeta(25-35) was significantly greater in this brain zone than in animals given water or the control peptide. Thus, Abeta(25-35) significantly increased cell proliferation in the subventricular zone after intracerebroventricular administration. | lld:pubmed |
| pubmed-article:20033317 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20033317 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033317 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20033317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033317 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20033317 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20033317 | pubmed:issn | 1573-899X | lld:pubmed |
| pubmed-article:20033317 | pubmed:author | pubmed-author:LazarevaN ANA | lld:pubmed |
| pubmed-article:20033317 | pubmed:author | pubmed-author:OnufrievM VMV | lld:pubmed |
| pubmed-article:20033317 | pubmed:author | pubmed-author:GulyaevaN VNV | lld:pubmed |
| pubmed-article:20033317 | pubmed:author | pubmed-author:StepanichevM... | lld:pubmed |
| pubmed-article:20033317 | pubmed:author | pubmed-author:MoiseevaYu... | lld:pubmed |
| pubmed-article:20033317 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20033317 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:20033317 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20033317 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20033317 | pubmed:pagination | 123-6 | lld:pubmed |
| pubmed-article:20033317 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:meshHeading | pubmed-meshheading:20033317... | lld:pubmed |
| pubmed-article:20033317 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20033317 | pubmed:articleTitle | Changes in cell proliferation in the subventricular zone of the brain in adult rats given beta-amyloid peptide (25-35). | lld:pubmed |
| pubmed-article:20033317 | pubmed:affiliation | Laboratory for the Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia. | lld:pubmed |
| pubmed-article:20033317 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20033317 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:54226 | entrezgene:pubmed | pubmed-article:20033317 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20033317 | lld:entrezgene |
