| pubmed-article:20023635 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20023635 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20023635 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:20023635 | lifeskim:mentions | umls-concept:C0682638 | lld:lifeskim |
| pubmed-article:20023635 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:20023635 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:20023635 | lifeskim:mentions | umls-concept:C1517503 | lld:lifeskim |
| pubmed-article:20023635 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20023635 | pubmed:dateCreated | 2010-1-8 | lld:pubmed |
| pubmed-article:20023635 | pubmed:abstractText | The B cell lymphoma-6 (Bcl-6) and Bcl-xL proteins are expressed in germinal center B cells and enable them to endure the proliferative and mutagenic environment of the germinal center. By introducing these genes into peripheral blood memory B cells and culturing these cells with two factors produced by follicular helper T cells, CD40 ligand (CD40L) and interleukin-21 (IL-21), we convert them to highly proliferating, cell surface B cell receptor (BCR)-positive, immunoglobulin-secreting B cells with features of germinal center B cells, including expression of activation-induced cytidine deaminase (AID). We generated cloned lines of B cells specific for respiratory syncytial virus and used these cells as a source of antibodies that effectively neutralized this virus in vivo. This method provides a new tool to study B cell biology and signal transduction through antigen-specific B cell receptors and for the rapid generation of high-affinity human monoclonal antibodies. | lld:pubmed |
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| pubmed-article:20023635 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20023635 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20023635 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20023635 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20023635 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20023635 | pubmed:issn | 1546-170X | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:RadbruchAndre... | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:SpitsHergenH | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:KwakkenbosMar... | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:BogersWilly... | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:BeaumontTimT | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:MeiHenrikH | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:BakkerArjen... | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:ScheerenFeren... | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:LukensMichaël... | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:YasudaEtsukoE | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:DiehlSean ASA | lld:pubmed |
| pubmed-article:20023635 | pubmed:author | pubmed-author:Widjojoatmodj... | lld:pubmed |
| pubmed-article:20023635 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20023635 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:20023635 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20023635 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20023635 | pubmed:pagination | 123-8 | lld:pubmed |
| pubmed-article:20023635 | pubmed:dateRevised | 2011-5-5 | lld:pubmed |
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