| pubmed-article:19965652 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19965652 | lifeskim:mentions | umls-concept:C0225326 | lld:lifeskim |
| pubmed-article:19965652 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:19965652 | lifeskim:mentions | umls-concept:C0393022 | lld:lifeskim |
| pubmed-article:19965652 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19965652 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:19965652 | lifeskim:mentions | umls-concept:C0884118 | lld:lifeskim |
| pubmed-article:19965652 | lifeskim:mentions | umls-concept:C1708612 | lld:lifeskim |
| pubmed-article:19965652 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19965652 | pubmed:dateCreated | 2010-1-22 | lld:pubmed |
| pubmed-article:19965652 | pubmed:abstractText | Many tumors, including lymphomas, up-regulate expression of CD46 to escape destruction by complement. Tumor cells are therefore relatively resistant to therapy by monoclonal antibodies, which act through complement-dependent cytotoxicity (CDC). From an Escherichia coli expression library of adenovirus type 35 fiber knob mutants, we selected a variant (Ad35K(++)) that had a higher affinity to CD46 than did the natural Ad35 fiber knob. We demonstrated that incubation of lymphoma cells with recombinant Ad35K(++) protein resulted in transient removal of CD46 from the cell surface. Preincubation of lymphoma cells with Ad35K(++) sensitized cells to CDC, triggered by the CD20-specific monoclonal antibody rituximab. In xenograft models with human lymphoma cells, preinjection of Ad35K(++) dramatically increased the therapeutic effect of rituximab. Blood cell counts and organ histology were normal after intravenous injection of Ad35K(++) into mice that express human CD46. The presence of polyclonal anti-Ad35K(++) antibodies did not affect the ability of Ad35K(++) to enhance rituximab-mediated CDC in in vitro assays. The Ad35K(++)-based approach has potential implications in monoclonal antibody therapy of malignancies beyond the combination with rituximab. | lld:pubmed |
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| pubmed-article:19965652 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19965652 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19965652 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19965652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19965652 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19965652 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19965652 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:19965652 | pubmed:author | pubmed-author:LiuYingY | lld:pubmed |
| pubmed-article:19965652 | pubmed:author | pubmed-author:LieberAndréA | lld:pubmed |
| pubmed-article:19965652 | pubmed:author | pubmed-author:FanXiaolongX | lld:pubmed |
| pubmed-article:19965652 | pubmed:author | pubmed-author:HemminkiAksel... | lld:pubmed |
| pubmed-article:19965652 | pubmed:author | pubmed-author:WangHongjieH | lld:pubmed |
| pubmed-article:19965652 | pubmed:author | pubmed-author:LiZong-YiZY | lld:pubmed |
| pubmed-article:19965652 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19965652 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:19965652 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:19965652 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19965652 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19965652 | pubmed:pagination | 592-600 | lld:pubmed |
| pubmed-article:19965652 | pubmed:dateRevised | 2011-7-20 | lld:pubmed |
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