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pubmed-article:19935370pubmed:abstractTextMany models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A number of cell surface molecules expressed by Tregs have been found to inhibit Treg activity, the best characterized of which is the glucocorticoid-induced tumor necrosis factor receptor-related (GITR) protein.lld:pubmed
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pubmed-article:19935370pubmed:articleTitleGITR Blockade Facilitates Treg Mediated Allograft Survival.lld:pubmed
pubmed-article:19935370pubmed:affiliationDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.lld:pubmed
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