| pubmed-article:19933793 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19933793 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:19933793 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:19933793 | lifeskim:mentions | umls-concept:C0007732 | lld:lifeskim |
| pubmed-article:19933793 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19933793 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:19933793 | lifeskim:mentions | umls-concept:C1956756 | lld:lifeskim |
| pubmed-article:19933793 | lifeskim:mentions | umls-concept:C2930770 | lld:lifeskim |
| pubmed-article:19933793 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19933793 | pubmed:dateCreated | 2010-1-25 | lld:pubmed |
| pubmed-article:19933793 | pubmed:abstractText | The activity of the new cephalosporin CXA-101 (CXA), previously designated FR264205, was evaluated against a collection of 236 carbapenem-resistant P. aeruginosa isolates, including 165 different clonal types, from a Spanish multicenter (127-hospital) study. The MICs of CXA were compared to the susceptibility results for antipseudomonal penicillins, cephalosporins, carbapenems, aminoglycosides, and fluoroquinolones. The MIC of CXA in combination with tazobactam (4 and 8 microg/ml) was determined for strains with high CXA MICs. The presence of acquired beta-lactamases was investigated by isoelectric focusing and PCR amplification followed by sequencing. Additional beta-lactamase genes were identified by cloning and sequencing. The CXA MIC50/MIC90 for the complete collection of carbapenem-resistant P. aeruginosa isolates was 1/4 microg/ml, with 95.3% of the isolates showing an MIC of <or=8 microg/ml. Cross-resistance with any of the antibiotics tested was not observed; the MIC50/MIC90 of CXA-101 was still 1/4 when multidrug-resistant (MDR) strains (42% of all tested isolates) or AmpC-hyperproducing clones (53%) were analyzed. Almost all (10/11) of the strains showing a CXA MIC of >8 microg/ml produced a horizontally acquired beta-lactamase, including the metallo-beta-lactamase (MBL) VIM-2 (one strain), the extended-spectrum beta-lactamase (ESBL) PER-1 (one strain), several extended-spectrum OXA enzymes (OXA-101 [one strain], OXA-17 [two strains], and a newly described OXA-2 derivative [W159R] designated OXA-144 [four strains]), and a new BEL variant (BEL-3) ESBL (one strain), as identified by cloning and sequencing. Synergy with tazobactam in these 11 strains was limited, although 8 microg/ml reduced the mean CXA MIC by 2-fold. CXA is highly active against carbapenem-resistant P. aeruginosa isolates, including MDR strains. Resistance was restricted to still-uncommon strains producing an acquired MBL or ESBL. | lld:pubmed |
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| pubmed-article:19933793 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19933793 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19933793 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19933793 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19933793 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19933793 | pubmed:issn | 1098-6596 | lld:pubmed |
| pubmed-article:19933793 | pubmed:author | pubmed-author:OliverAntonio... | lld:pubmed |
| pubmed-article:19933793 | pubmed:author | pubmed-author:JuanCarlosC | lld:pubmed |
| pubmed-article:19933793 | pubmed:author | pubmed-author:GeYigongY | lld:pubmed |
| pubmed-article:19933793 | pubmed:author | pubmed-author:PérezJosé LJL | lld:pubmed |
| pubmed-article:19933793 | pubmed:author | pubmed-author:ZamoranoLaura... | lld:pubmed |
| pubmed-article:19933793 | pubmed:author | pubmed-author:Spanish... | lld:pubmed |
| pubmed-article:19933793 | pubmed:author | pubmed-author:Spanish... | lld:pubmed |
| pubmed-article:19933793 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19933793 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:19933793 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19933793 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19933793 | pubmed:pagination | 846-51 | lld:pubmed |
| pubmed-article:19933793 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
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| pubmed-article:19933793 | pubmed:meshHeading | pubmed-meshheading:19933793... | lld:pubmed |
| pubmed-article:19933793 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19933793 | pubmed:articleTitle | Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. | lld:pubmed |
| pubmed-article:19933793 | pubmed:affiliation | Servicio de Microbiología and Unidad de Investigación, Hospital Son Dureta, C. Andrea Doria no. 55, 07014 Palma de Mallorca, Spain. | lld:pubmed |
| pubmed-article:19933793 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19933793 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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