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| pubmed-article:1991447 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:1991447 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:1991447 | lifeskim:mentions | umls-concept:C1961133 | lld:lifeskim |
| pubmed-article:1991447 | lifeskim:mentions | umls-concept:C2673177 | lld:lifeskim |
| pubmed-article:1991447 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:1991447 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:1991447 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1991447 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1991447 | pubmed:dateCreated | 1991-3-13 | lld:pubmed |
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| pubmed-article:1991447 | pubmed:abstractText | We have isolated 10 closely linked members of a proteinase inhibitor multigene family from the inbred mouse strain 129. These sequences, termed the Serine Proteinase Inhibitor 2 (Spi-2) genes, appear to have been derived from a common ancestor represented in man by the single copy alpha 1-antichymotrypsin gene. The genes are clustered on two cloned genomic DNA segments spanning 220 kb, and have at least partially retained the intragenic structure of the ancestral Spi-2 gene. Sequence analysis from the final coding exon indicates that most of the mouse genes may be competent to encode functional proteins, some with a predictable inhibitory spectrum, and several representing novel inhibitor types. An oligonucleotide probe designed to one reactive centre sequence enabled the isolation of the cognate expressed transcript from a liver cDNA library. However, whether expressed or not, the reactive centre regions of all the sequences have diverged at a rapid rate relative to structurally defined flanking sequences. The divergence is also appreciably greater than that occurring in an adjacent non-coding sequence. This phenomenon has established novel potential inhibitory specificities, while maintaining a functional inhibitor structure. | lld:pubmed |
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| pubmed-article:1991447 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1991447 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1991447 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1991447 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1991447 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1991447 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:1991447 | pubmed:author | pubmed-author:HillR ERE | lld:pubmed |
| pubmed-article:1991447 | pubmed:author | pubmed-author:InglisJ DJD | lld:pubmed |
| pubmed-article:1991447 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1991447 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:1991447 | pubmed:geneSymbol | Spi-2 | lld:pubmed |
| pubmed-article:1991447 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1991447 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1991447 | pubmed:pagination | 255-61 | lld:pubmed |
| pubmed-article:1991447 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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