| pubmed-article:19883630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C0919458 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C0906368 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19883630 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19883630 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19883630 | pubmed:dateCreated | 2010-1-27 | lld:pubmed |
| pubmed-article:19883630 | pubmed:abstractText | Multidrug resistance-associated protein (MRP-1/ABCC1) transports a wide range of therapeutic agents and may play a critical role in the development of multidrug resistance (MDR) in tumor cells. However, the regulation of MRP-1 remains controversial. To explore whether miRNAs are involved in the regulation of MRP-1 expression and modulate the sensitivity of tumor cells to chemotherapeutic agents, we analyzed miRNA expression levels in VP-16-resistant MDR cell line, MCF-7/VP, in comparison with its parent cell line, MCF-7, using a miRNA microarray. MCF-7/VP overexpressed MRP-1 mRNA and protein not MDR-1 and BCRP. miR-326 was downregulated in MCF-7/VP compared to MCF-7. Additionally, miR-326 was downregulated in a panel of advanced breast cancer tissues and consistent reversely with expression levels of MRP-1. Furthermore, the elevated levels of miR-326 in the mimics-transfected VP-16-resistant cell line, MCF-7/VP, downregulated MRP-1 expression and sensitized these cells to VP-16 and doxorubicin. These findings demonstrate for the first time the involvement of miRNAs in multidrug resistance mediated by MRP-1 and suggest that miR-326 may be an efficient agent for preventing and reversing MDR in tumor cells. | lld:pubmed |
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| pubmed-article:19883630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19883630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19883630 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19883630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19883630 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19883630 | pubmed:issn | 1873-2968 | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:HuckoMM | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:LiangZhongxin... | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:WuHuiH | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:LiYuhuaY | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:ZhangYaweiY | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:ScalaStefania... | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:XiaJamesJ | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:ShimHyunsukH | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:ChoHeidi THT | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:YoonYounghyou... | lld:pubmed |
| pubmed-article:19883630 | pubmed:author | pubmed-author:WagarNicholas... | lld:pubmed |
| pubmed-article:19883630 | pubmed:copyrightInfo | Copyright 2009 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:19883630 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19883630 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19883630 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:19883630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19883630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19883630 | pubmed:pagination | 817-24 | lld:pubmed |
| pubmed-article:19883630 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19883630 | pubmed:meshHeading | pubmed-meshheading:19883630... | lld:pubmed |
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| pubmed-article:19883630 | pubmed:meshHeading | pubmed-meshheading:19883630... | lld:pubmed |
| pubmed-article:19883630 | pubmed:meshHeading | pubmed-meshheading:19883630... | lld:pubmed |
| pubmed-article:19883630 | pubmed:meshHeading | pubmed-meshheading:19883630... | lld:pubmed |
| pubmed-article:19883630 | pubmed:meshHeading | pubmed-meshheading:19883630... | lld:pubmed |
| pubmed-article:19883630 | pubmed:meshHeading | pubmed-meshheading:19883630... | lld:pubmed |
| pubmed-article:19883630 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19883630 | pubmed:articleTitle | Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. | lld:pubmed |
| pubmed-article:19883630 | pubmed:affiliation | Department of Radiology, Emory University, Atlanta, GA 30322, USA. zliang@emory.edu | lld:pubmed |
