| pubmed-article:1986214 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1986214 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:1986214 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:1986214 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:1986214 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1986214 | lifeskim:mentions | umls-concept:C0549178 | lld:lifeskim |
| pubmed-article:1986214 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1986214 | lifeskim:mentions | umls-concept:C1524057 | lld:lifeskim |
| pubmed-article:1986214 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1986214 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1986214 | pubmed:dateCreated | 1991-2-14 | lld:pubmed |
| pubmed-article:1986214 | pubmed:abstractText | Inactivation of the cellular p53 gene is a common feature of Friend virus-induced murine erythroleukemia cell lines and may represent a necessary step in the progression of this disease. As well, frequent loss or mutation of p53 alleles in diverse human tumors is consistent with the view of p53 as a tumor suppressor gene. To examine the significance of p53 gene inactivation in tumorigenesis, we have attempted to express transfected wild-type p53 in three p53-negative tumor cell lines: murine DP16-1 Friend erythroleukemia cells, human K562 cells, and SKOV-3 cells. We found that aberrant p53 proteins, which differ from wild-type p53 by a single amino acid substitution, were expressed stably in these cells, whereas wild-type p53 expression was not tolerated. The inability of p53-negative tumor cell lines to support long-term expression of wild-type p53 protein is consistent with the view that p53 is a tumor suppressor gene. | lld:pubmed |
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| pubmed-article:1986214 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1986214 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1986214 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1986214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1986214 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1986214 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1986214 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1986214 | pubmed:author | pubmed-author:MowatMM | lld:pubmed |
| pubmed-article:1986214 | pubmed:author | pubmed-author:JohnsonPP | lld:pubmed |
| pubmed-article:1986214 | pubmed:author | pubmed-author:BenchimolSS | lld:pubmed |
| pubmed-article:1986214 | pubmed:author | pubmed-author:GrayDD | lld:pubmed |
| pubmed-article:1986214 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1986214 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1986214 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1986214 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1986214 | pubmed:pagination | 1-11 | lld:pubmed |
| pubmed-article:1986214 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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