| pubmed-article:1986065 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C0032824 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:1986065 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1986065 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1986065 | pubmed:dateCreated | 1991-2-14 | lld:pubmed |
| pubmed-article:1986065 | pubmed:abstractText | Several calcium-dependent potassium currents can contribute to the electrophysiological properties of neurons. In hippocampal pyramidal cells, 2 afterhyperpolarizations (AHPs) are mediated by different calcium-activated potassium currents. First, a rapidly activated current contributes to action-potential repolarization and the fast AHP following individual action potentials. In addition, a slowly developing current underlies the slow AHP, which occurs after a burst of action potentials and contributes substantially to the spike-frequency accommodation observed in these cells during a prolonged depolarizing current pulse. In order to investigate the single Ca2(+)-dependent channels that might underlie these currents, we performed patch-clamp experiments on hippocampal neurons in primary culture. When excised inside-out patches were exposed to 1 microM Ca2+, 2 types of channel activity were observed. In symmetrical bathing solutions containing 140 mM K+, the channels had conductances of 19 pS and 220 pS, and both were permeable mainly to potassium ions. The properties of these 2 channels differed in a number of ways. At negative membrane potentials, the small-conductance channels were more sensitive to Ca2+ than the large channels. At positive potentials, the small-conductance channels displayed a flickery block by Mg2+ ions on the cytoplasmic face of the membrane. Low concentrations of tetraethylammonium (TEA) on the extracellular face of the membrane specifically caused an apparent reduction of the large-channel conductance. The properties of the large- and small-conductance channels are in accord with those of the fast and slow AHP, respectively. | lld:pubmed |
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| pubmed-article:1986065 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1986065 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1986065 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1986065 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1986065 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1986065 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:1986065 | pubmed:author | pubmed-author:NicollR ARA | lld:pubmed |
| pubmed-article:1986065 | pubmed:author | pubmed-author:PerkelD JDJ | lld:pubmed |
| pubmed-article:1986065 | pubmed:author | pubmed-author:LancasterBB | lld:pubmed |
| pubmed-article:1986065 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1986065 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1986065 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1986065 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1986065 | pubmed:pagination | 23-30 | lld:pubmed |
| pubmed-article:1986065 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1986065 | pubmed:meshHeading | pubmed-meshheading:1986065-... | lld:pubmed |
| pubmed-article:1986065 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1986065 | pubmed:articleTitle | Calcium activates two types of potassium channels in rat hippocampal neurons in culture. | lld:pubmed |
| pubmed-article:1986065 | pubmed:affiliation | Department of Pharmacology, University of California, San Francisco 94143. | lld:pubmed |
| pubmed-article:1986065 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1986065 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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