| pubmed-article:19838200 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19838200 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:19838200 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:19838200 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:19838200 | lifeskim:mentions | umls-concept:C1420841 | lld:lifeskim |
| pubmed-article:19838200 | lifeskim:mentions | umls-concept:C2698300 | lld:lifeskim |
| pubmed-article:19838200 | lifeskim:mentions | umls-concept:C0814022 | lld:lifeskim |
| pubmed-article:19838200 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:19838200 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:19838200 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:19838200 | pubmed:dateCreated | 2009-11-16 | lld:pubmed |
| pubmed-article:19838200 | pubmed:abstractText | The survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influx in naive T lymphocytes is unknown. Here we report an essential role for the beta3 regulatory subunit of voltage-gated calcium (Ca(v)) channels in the maintenance of naive CD8(+) T cells. Deficiency in beta3 resulted in a profound survival defect of CD8(+) T cells. This defect correlated with depletion of the pore-forming subunit Ca(v)1.4 and attenuation of T cell antigen receptor (TCR)-mediated global Ca(2+) entry in CD8(+) T cells. Ca(v)1.4 and beta3 associated with T cell signaling machinery and Ca(v)1.4 localized in lipid rafts. Our data demonstrate a mechanism by which Ca(2+) entry is controlled by a Ca(v)1.4-beta3 channel complex in T cells. | lld:pubmed |
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| pubmed-article:19838200 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19838200 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19838200 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19838200 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19838200 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19838200 | pubmed:issn | 1529-2916 | lld:pubmed |
| pubmed-article:19838200 | pubmed:author | pubmed-author:FlavellRichar... | lld:pubmed |
| pubmed-article:19838200 | pubmed:author | pubmed-author:McRoryJohn... | lld:pubmed |
| pubmed-article:19838200 | pubmed:author | pubmed-author:FlockerziVeit... | lld:pubmed |
| pubmed-article:19838200 | pubmed:author | pubmed-author:FreichelMarcM | lld:pubmed |
| pubmed-article:19838200 | pubmed:author | pubmed-author:BadouAbdallah... | lld:pubmed |
| pubmed-article:19838200 | pubmed:author | pubmed-author:MeissnerMarce... | lld:pubmed |
| pubmed-article:19838200 | pubmed:author | pubmed-author:JhaMithilesh... | lld:pubmed |
| pubmed-article:19838200 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19838200 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:19838200 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19838200 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19838200 | pubmed:pagination | 1275-82 | lld:pubmed |
| pubmed-article:19838200 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:meshHeading | pubmed-meshheading:19838200... | lld:pubmed |
| pubmed-article:19838200 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19838200 | pubmed:articleTitle | Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels. | lld:pubmed |
| pubmed-article:19838200 | pubmed:affiliation | Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA. | lld:pubmed |
| pubmed-article:19838200 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19838200 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12297 | entrezgene:pubmed | pubmed-article:19838200 | lld:entrezgene |
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