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pubmed-article:1980381pubmed:abstractTextTwenty-one immunodeficiency virus 1 (HIV 1)-positive hemophilic patients were treated with Azidothymidine (AZT) for symptomatic HIV infection. The median observation period was 20.5 months. At 25 months the probability of survival was 82%, the probability of progression of disease from CDC III or IV C2 to IV C1 (AIDS) was 20% in patients on continuous AZT treatment and 50% in patients with interruption of treatment. Three patients developed severe leukopenia and 3 patients severe anemia during AZT treatment. In 1 patient a dose-dependent striking increase of transaminases during AZT treatment was observed. In 7 patients treatment was interrupted, in 1 patient because of anemia, in 1 because of pruritus and in 5 patients because of non-compliance. No significant changes in the consumption of clotting factor concentrates and number of bleeding episodes before and during AZT treatment were noted. We conclude, that both hematological and non-hematological side effects of AZT in HIV 1-infected hemophilic patients are comparable to those seen in other risk groups. AZT does not increase the bleeding tendency in this patient group.lld:pubmed
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pubmed-article:1980381pubmed:articleTitleAzidothymidine (AZT) in the treatment of symptomatic HIV-1-infected hemophiliacs.lld:pubmed
pubmed-article:1980381pubmed:affiliationFirst Department of Medicine, University of Vienna, Austria.lld:pubmed
pubmed-article:1980381pubmed:publicationTypeJournal Articlelld:pubmed