| pubmed-article:1980114 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C0079864 | lld:lifeskim |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1980114 | lifeskim:mentions | umls-concept:C0599991 | lld:lifeskim |
| pubmed-article:1980114 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1980114 | pubmed:dateCreated | 1991-2-20 | lld:pubmed |
| pubmed-article:1980114 | pubmed:abstractText | Some strains of mice inoculated with LP-BM5 murine leukemia virus (MuLV) develop a syndrome, termed mouse acquired immunodeficiency syndrome (MAIDS), characterized by progressive lymphoproliferation and profound immunodeficiency. LP-BM5 MuLV is a virus mixture that contains ecotropic (eco) and mink cell focus-induced MuLV and a defective genome that is the proximal cause of disease. Flow cytometry analyses of spleen and lymph nodes from susceptible C57BL/6 mice infected with this virus mixture revealed the presence in spleen and peripheral lymph nodes of a previously unrecognized subset of CD4+CD3+ T cells that are Thy-1-. The frequency of these cells increased with progression of disease, eventually comprising between 30% and 50% of all CD4+ cells. Infection of A/J mice, a strain which is genetically resistant to development of MAIDS, did not induce an increase of this T cell population, indicating that infection with the virus mixture was insufficient to induce its proliferation. A central role for the defective virus in this process was suggested by the finding that C57BL/6 mice infected with LP-BM5 eco alone did not have increased frequencies of Thy-1-CD4+ cells in spleen. Studies of spleen and peripheral lymph node cells from normal mice demonstrated the presence of Thy-1-CD4+ cells at frequencies of 1%-2%. Studies using two anti-T cell monoclonal antibodies, SM6C10 and SM3G11, that define four CD4+ subsets showed that Thy-1-CD4+ T cells from normal and infected mice were present only in the 6C10- subsets. | lld:pubmed |
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| pubmed-article:1980114 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1980114 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1980114 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1980114 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1980114 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1980114 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1980114 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1980114 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1980114 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:1980114 | pubmed:author | pubmed-author:MorseH CHC3rd | lld:pubmed |
| pubmed-article:1980114 | pubmed:author | pubmed-author:MakinoMM | lld:pubmed |
| pubmed-article:1980114 | pubmed:author | pubmed-author:HayakawaKK | lld:pubmed |
| pubmed-article:1980114 | pubmed:author | pubmed-author:HardyR RRR | lld:pubmed |
| pubmed-article:1980114 | pubmed:author | pubmed-author:HolmesK LKL | lld:pubmed |
| pubmed-article:1980114 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1980114 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:1980114 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1980114 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1980114 | pubmed:pagination | 2783-7 | lld:pubmed |
| pubmed-article:1980114 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1980114 | pubmed:meshHeading | pubmed-meshheading:1980114-... | lld:pubmed |
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| pubmed-article:1980114 | pubmed:meshHeading | pubmed-meshheading:1980114-... | lld:pubmed |
| pubmed-article:1980114 | pubmed:meshHeading | pubmed-meshheading:1980114-... | lld:pubmed |
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| pubmed-article:1980114 | pubmed:meshHeading | pubmed-meshheading:1980114-... | lld:pubmed |
| pubmed-article:1980114 | pubmed:meshHeading | pubmed-meshheading:1980114-... | lld:pubmed |
| pubmed-article:1980114 | pubmed:meshHeading | pubmed-meshheading:1980114-... | lld:pubmed |
| pubmed-article:1980114 | pubmed:meshHeading | pubmed-meshheading:1980114-... | lld:pubmed |
| pubmed-article:1980114 | pubmed:meshHeading | pubmed-meshheading:1980114-... | lld:pubmed |
| pubmed-article:1980114 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1980114 | pubmed:articleTitle | A unique subset of normal murine CD4+ T cells lacking Thy-1 is expanded in a murine retrovirus-induced immunodeficiency syndrome, MAIDS. | lld:pubmed |
| pubmed-article:1980114 | pubmed:affiliation | Biological Resources Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:1980114 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1980114 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1980114 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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