| pubmed-article:19800225 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0034818 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0005117 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19800225 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:19800225 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:19800225 | pubmed:dateCreated | 2009-10-12 | lld:pubmed |
| pubmed-article:19800225 | pubmed:abstractText | Berberine (BBR) is a natural compound with up-regulating activity on both low-density-lipoprotein receptor (LDLR) and insulin receptor (InsR). This one-drug-multiple-target characteristic might be suitable for the treatment of metabolic syndrome. In searching for up-regulators effective for both LDLR and InsR expression, the structure-activity relationship (SAR) analysis for BBR analogues was done. Fourteen BBR analogues were designed, synthesized and biologically evaluated. SAR analysis revealed that appropriate modifications on the phenyl ring A or D of BBR might retain the up-regulatory activities on the expression of both LDLR and InsR. Among these compounds, compound 13a bearing 9-methoxy and 10-hydroxyl on the ring D showed promising activities on either LDLR or InsR gene expression. The 10-hydroxyl of 13a could be an arm to connect proper chemical groups for optimizing drug-bioavailability in vivo. Thus, 13a could be considered to be a parent compound to make pro-drugs for either blood lipids or glucose. | lld:pubmed |
| pubmed-article:19800225 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19800225 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19800225 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19800225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19800225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19800225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19800225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19800225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19800225 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19800225 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19800225 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:CoxP NPN | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:TurkJ BJB | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:ZhangHaoH | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:WangYu-PingYP | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:JiangJian-Don... | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:SongDan-QingD... | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:KongWei-JiaWJ | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:LiYing-HongYH | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:WangYan-Xiang... | lld:pubmed |
| pubmed-article:19800225 | pubmed:author | pubmed-author:GaoRong-MeiRM | lld:pubmed |
| pubmed-article:19800225 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19800225 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19800225 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19800225 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19800225 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19800225 | pubmed:pagination | 6004-8 | lld:pubmed |
| pubmed-article:19800225 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:meshHeading | pubmed-meshheading:19800225... | lld:pubmed |
| pubmed-article:19800225 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19800225 | pubmed:articleTitle | Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor. | lld:pubmed |
| pubmed-article:19800225 | pubmed:affiliation | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. | lld:pubmed |
| pubmed-article:19800225 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19800225 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19800225 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19800225 | lld:pubmed |
