| pubmed-article:1977160 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1977160 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1977160 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1977160 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:1977160 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:1977160 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1977160 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:1977160 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:1977160 | pubmed:dateCreated | 1990-11-9 | lld:pubmed |
| pubmed-article:1977160 | pubmed:abstractText | The fluorescent vital dye rhodamine 123 (Rh-123), which preferentially accumulates in mitochondrial membranes, can be used as a probe to indicate mitochondrial and hence cellular activity. In this study, mouse bone marrow hematopoietic stem cells were subdivided into Rh-123lo, Rh-123med, and Rh-123hi populations. The Rh-123lo (resting) population was significantly enriched in cells with a higher proliferative potential compared to the Rh-123hi (activated) population. The resting population exhibited a 20-fold greater ability to differentiate into splenic colony-forming units (CFU-S) relative to the activated population, whereas the activated population contained about 4-fold more day 13 CFU-S on primary transfer relative to the resting population. The two populations produced morphologically distinct splenic colonies; however, the frequency and morphology of in vitro colonies were very similar. Only the resting population provided sufficient stem cells to transfer long-term hematopoietic repopulation to secondary recipient animals after lethal irradiation. On a single cell level, the resting and activated populations exhibited an equivalent ability to differentiate into lymphoid and myeloid progeny. These observations provide further insight into the heterogeneous nature of CFU-S and directly demonstrate that multipotent hematopoietic stem cells are heterogeneous with regard to their clonogenic capacities. | lld:pubmed |
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| pubmed-article:1977160 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1977160 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1977160 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1977160 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1977160 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1977160 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1977160 | pubmed:author | pubmed-author:JohnsonG RGR | lld:pubmed |
| pubmed-article:1977160 | pubmed:author | pubmed-author:SpangrudeG... | lld:pubmed |
| pubmed-article:1977160 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1977160 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:1977160 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1977160 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1977160 | pubmed:pagination | 7433-7 | lld:pubmed |
| pubmed-article:1977160 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1977160 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1977160 | pubmed:articleTitle | Resting and activated subsets of mouse multipotent hematopoietic stem cells. | lld:pubmed |
| pubmed-article:1977160 | pubmed:affiliation | Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia. | lld:pubmed |
| pubmed-article:1977160 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1977160 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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